Effects of endurance exercise training on endoplasmic reticulum stress in pancreatic islets of obese mice

Author(s)

Marconato-Junior, E. ; Soares, G. M. ; Rodrigues-dos-Santos, K. ; Araujo, T. dos Reis ; Vettorazzi, J. F. ; Zangerolamo, L. ; Costa-Junior, J. M. ; Carneiro, E. M. ; Boschero, A. C. ; Barbosa, H. C. L.

• Document type: Journal article
• Source: Brazilian Journal of Medical and Biological Research; v. 58, p. 9-pg., 2025-01-01.

Abstract

Obesity is a serious health problem worldwide and the search for new control methods and therapies is imperative. Studies indicate that a variety of obesogenic diets may increase the risk of developing type 2 diabetes mellitus (T2D) by causing insulin resistance in peripheral tissues. The chronic increase in free fatty acids associated with obesity may increase insulin demand by pancreatic beta cells and induce intrinsic beta cell dysfunction through endoplasmic reticulum (ER) stress, which is associated with beta cell loss during the development of T2D. Physical exercise approaches have been emerging as powerful tools and adjuncts in a variety of conditions, improving glucose homeostasis, oxygen uptake, and metabolism. Here, we showed that a 16-week endurance training program mitigated the deleterious effects of an obesogenic diet on glycemic homeostasis, insulin secretion, and ER stress markers as well as islet health markers in C57/BL6 obese mice. The results corroborated the assumption that physical exercise is an effective therapy to avoid beta cell death in glucose metabolism dysfunction and T2D in obese individuals. (AU)

• FAPESP's process: 18/06363-1 - Therapeutic potential of GHRH and metformin on pancreatic beta cell function against endoplasmic reticulum stress and type 2 diabetes mellitus progress
• Grantee: Helena Cristina de Lima Barbosa
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/14020-7 - Molecular and functional mechanisms involved in the central effects of FGF19 on hypothalamic dysregulation
• Grantee: Lucas Zangerolamo
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 21/04664-7 - Molecular mechanisms involved in pancreatic beta cell dysfunction and death in Diabetes Mellitus: strategies for the inhibition of these processes and restoration of the insular mass
• Grantee: Antonio Carlos Boschiero
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/26080-4 - Characterization of molecular and functional mechanisms involved in endocrine-metabolic, cardiovascular and neural dysfunctions induced by the restriction of amino acids in vitro and in vivo: possible therapeutic role of bile acid TUDCA
• Grantee: Everardo Magalhães Carneiro
• Support Opportunities: Research Projects - Thematic Grants