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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Diuron exposure induces systemic and organ-specific toxicity following acute and sub-chronic exposure in male Wistar rats

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Author(s):
Domingues, Alexandre [1] ; Barbisan, Luis Fernando [2] ; Martins, Priscila Raquel [3] ; Tozzi Spinardi-Barbisan, Ana Lucia [1]
Total Authors: 4
Affiliation:
[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Pathol, BR-18618970 Botucatu, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP - Brazil
[3] Scio Paulo State Univ UNESP, Inst Biosci, Dept Microbiol & Immunol, BR-18618970 Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY; v. 31, n. 3, p. 387-396, MAY 2011.
Web of Science Citations: 9
Abstract

Diuron {[}3-(3,4-dichloropheny1)-1,1-dimethylurea] is a substitute urea herbicide widely used on agricultural crops with potential mutagenic, teratogenic, reproductive and carcinogenic effects. Nonetheless, its toxic potential on the immune system needs a detailed assessment. Thus, in order to evaluate the adverse effect of this herbicide on lymphohematopoietic organs and macrophage activity, male Wistar rats were orally treated with Diuron at 125, 1250 and 2500 ppm for 14, 28 or 90 days. General signs of toxicity were observed in Diuron-treated groups (1250 and 2500 ppm), including reduced food intake and body weight gain, as well as higher relative weights for spleen, kidneys and liver (28 and 90-day toxicity studies) and elevated serum levels of ALT, albumin, total protein, creatinine and urea (28-day toxicity study). Diuron exposure caused a severe depletion of splenic white pulp compartments and cellularity, followed by a decreased number of CD4(+) T lymphocytes, increased extramedullary hematopoiesis and deposition of hemosiderin in red pulp. Despite alteration in macrophage spreading, the macrophagic activity was not significantly affected by the herbicide. Under these experimental conditions, the results suggest that Diuron exerts systemic and target-organ toxicity, mainly at higher concentration. (C) 2011 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 05/01223-7 - Evaluation of immunotoxic potential of diuron herbicide: acute and sub-chronic toxicity study of repeated doses
Grantee:Alexandre Domingues
Support type: Scholarships in Brazil - Master