| Full text | |
| Author(s): |
Brunetta, Henver S.
;
Zani, Stepheny C. de Campos
;
Ruiz, Gabriel P.
;
Mori, Marcelo A.
Total Authors: 4
|
| Document type: | Journal article |
| Source: | CURRENT OPINION IN ENDOCRINE AND METABOLIC RESEARCH; v. 38, p. 6-pg., 2025-03-01. |
| Abstract | |
microRNAs (miRNAs) secreted by the adipose tissue (AT) have gained substantial attention over the last decade. Adipocytes produce and secrete large amounts of miRNAs that, in turn, can mediate physiological processes paracrinally or in distant organs. It is now clear that AT-derived miRNAs are important players in the development of obesity-associated comorbidities. Here, we provide an overview that supports this notion and bring insights into the intricate involvement of AT-derived miRNAs in the pathogenesis of cardiometabolic diseases, discussing some of their far-reaching effects on the liver, heart, vasculature, and other tissues. Moreover, we outline future research directions addressing current gaps in the field which we hope will further advance our comprehension of the role of AT-derived miRNAs. (AU) | |
| FAPESP's process: | 19/21852-1 - Contribution of adipose tissue miRNAs in cardiac function, metabolism and remodeling |
| Grantee: | Henver Simionato Brunetta |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 21/08354-2 - The interplay between the immune system and metabolism as a key determinant of the aging process |
| Grantee: | Marcelo Alves da Silva Mori |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/21635-8 - Study of the role of miR-203-3p in adipose tissue metabolism and in the pathogenesis of metabolic diseases in mice |
| Grantee: | Gabriel Palermo Ruiz |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 22/00358-1 - Crosstalk between adipocyte-derived miRNA-802 and heart GATA4: a potential novel endocrine mechanism controlling heart remodeling and function |
| Grantee: | Henver Simionato Brunetta |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 23/07882-0 - Exploring the role of adipose tissue-derived microRNAs in obesity- and lipodystrophy-induced non-alcoholic fatty liver disease |
| Grantee: | Stepheny Carneiro de Campos |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |