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Study of the role of miR-203-3p in adipose tissue metabolism and in the pathogenesis of metabolic diseases in mice

Grant number: 18/21635-8
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2019
Effective date (End): February 28, 2023
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Marcelo Alves da Silva Mori
Grantee:Gabriel Palermo Ruiz
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:17/01184-9 - CAMeLEOm: cross-species analysis of metabolic, lifespan effects and omics of dietary restriction mimetics, AP.TEM

Abstract

The Metabolic Syndrome affects 25% of the adult population, emerging as one of the largest public health concerns worldwide, being Obesity and insulin resistance extremely relevant in this context. Caloric restriction and physical exercise appear as important interventions to treat metabolic diseases, however, the cellular and molecular components that participate in the beneficial effects of these interventions are not completely elucidated. It is known that adipose tissue microRNAs (miRNAs) are regulated under these conditions and that miR-203-3p is articularly decreased in Obesity and increased in response to physical exercise and caloric restriction. Preliminary data from our group point to miR203-3p as a candidate to mediate metabolic adaptation under energetic stress conditions. However, this miRNA is barely explored in the context of metabolism and studies are required to characterize its functions in vivo. Thus, we propose to generate adipocyte-specific mir203 knockout mice seeking to understand the function of miR-203-3p in adipose tissue in vivo, its role in the metabolic adaptation to caloric restriction and physical exercise, as well as its possible therapeutic role in metabolic disorders. In parallel, we will evaluate, in vivo and in vitro, a possible role for adipose tissue miR-203-3p in intertissue communication. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Research details how aerobic exercise reverses degenerative process that leads to metabolic diseases 
Articles published in other media outlets (76 total):
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Technology Org: Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (30/Dec/2020)
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ProNews (Grécia): Αντιγήρανση: Αυτά είναι τα οφέλη της αερόβιας άσκησης (11/Dec/2020)
Weibo (China): Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (11/Dec/2020)
HXJKA (China): 肥胖糖尿病人要注意,减肥与有氧运动可以逆转危害、改善健康 - Pessoas obesas com diabetes devem prestar atenção, pois a perda de peso e os exercícios aeróbicos podem reverter os danos e melhorar a saúde (10/Dec/2020)
Gossip Rodos (Grécia): Αντιγήρανση: Τα οφέλη της αερόβιας άσκησης - Anti-envelhecimento: os benefícios do exercício aeróbico (10/Dec/2020)
Onmed.gr (Grécia): Αντιγήρανση: Τα οφέλη της αερόβιας άσκησης (10/Dec/2020)
Multi-news.gr (Grécia): Αντιγήρανση: Τα οφέλη της αερόβιας άσκησης (10/Dec/2020)
Medindia (Índia): Aerobic Exercise Can Halt Degenerative Process (09/Dec/2020)
Ygeiamou (Grécia): Μεταβολικές νόσοι: Η κίνηση – κλειδί που τις αναστρέφει και καταπολεμά τη γήρανση (09/Dec/2020)
Ebiotrade.com (China): Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (09/Dec/2020)
Cretalive News (Grécia): Μεταβολικές νόσοι: Η κίνηση – κλειδί που τις αναστρέφει (09/Dec/2020)
Biology 360 (China): Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (09/Dec/2020)
Patrastimes.gr (Grécia): Μεταβολικές νόσοι: Η κίνηση – κλειδί που τις αναστρέφει και καταπολεμά τη γήρανση (09/Dec/2020)
Patrastimes.gr (Grécia): Η αεροβική γυμναστική επιδρά στις μεταβολικές οδούς του οργανισμού (09/Dec/2020)
Coollife.gr (Grécia): Μεταβολικές νόσοι: Η κίνηση – κλειδί που τις αναστρέφει και καταπολεμά τη γήρανση (09/Dec/2020)
iFitnessbook.com (Grécia): Μεταβολικές νόσοι: Η κίνηση-κλειδί που τις αναστρέφει και καταπολεμά τη γήρανση (09/Dec/2020)
Instrument Information Network (China): Study details how aerobic exercise reverses degenerative process that leads to metabolic disease (09/Dec/2020)
News Medical (Austrália): Degenerative process can be reversed by practicing regular aerobic exercise, shows study (08/Dec/2020)
Brinkwire (Reino Unido): Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (08/Dec/2020)
Health Problems News: Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (08/Dec/2020)
NewsBeezer: The degenerative process can be reversed with regular aerobic exercise, a study shows (08/Dec/2020)
Bariatric News online: Aerobic exercise reverses degenerative process that leads to metabolic diseases (08/Dec/2020)
Blog Dady (Índia): Degenerative course of might be reversed by practising common cardio train, reveals research (08/Dec/2020)
Pourquoi Docteur (França): L’exercice aérobie permet d’éviter les maladies métaboliques (08/Dec/2020)
Knowledia (França): Degenerative process can be reversed by practicing regular aerobic exercise, shows study (08/Dec/2020)
Zougla.gr (Grécia): Mελέτη δείχνει πώς η αερόβια άσκηση ενισχύει τη μεταβολική διαδικασία (08/Dec/2020)
Iran Daily (Irã) online: Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (08/Dec/2020)
HealthyLiving.gr (Grécia): Πώς η άσκηση βελτιώνει το μεταβολισμό (08/Dec/2020)
Nature BIO1000 (China): Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (08/Dec/2020)
RadioVera.gr - ΡΑΔΙΟ ΒΕΡΑ FM 91,8 (Grécia): Mελέτη δείχνει πώς η αερόβια άσκηση ενισχύει τη μεταβολική διαδικασία (08/Dec/2020)
Nano Medicine: Degenerative process can be reversed by practicing regular aerobic exercise, shows study (08/Dec/2020)
Medical Xpress (Reino Unido): Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (07/Dec/2020)
Bioengineer (Reino Unido): Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (07/Dec/2020)
Science Codex: Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (07/Dec/2020)
ClinicalNews (EUA): Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (07/Dec/2020)
Scienmag Science Magazine (Reino Unido): Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (07/Dec/2020)
Brightsurf: Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (07/Dec/2020)
Il Mio Diabete (Itália): L’esercizio aerobico inverte il processo degenerativo che porta a malattie metaboliche (07/Dec/2020)
7thSpace: Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (07/Dec/2020)
Reddit (EUA): Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (07/Dec/2020)
Science News Net: Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (07/Dec/2020)
Tech and Science Post: Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (07/Dec/2020)
Oullins-Patriote.com: Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (07/Dec/2020)
Healthy News Info: Research particulars how cardio train reverses degenerative course of that results in metabolic illnesses (07/Dec/2020)
White Newspaper: Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (07/Dec/2020)
Xsjk (China): Study details how aerobic exercise reverses degenerative process that leads to metabolic diseases (06/Dec/2020)
Centralx: Exercício aeróbico estimula expressão da enzima DICER, desencadeando benefícios metabólicos através do aumento na produção de microRNAs (17/Nov/2020)
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TNH1: Este tipo de exercício pode ajudar no combate de doenças metabólicas (08/Nov/2020)
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Plantão News (MT): Estudo detalha como o exercício aeróbico reverte o processo degenerativo de doenças metabólicas (07/Nov/2020)
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