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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biological monitoring of a xenomaterial for grafting: an evaluation in critical-size calvarial defects

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Accorsi-Mendonca, Thais [1] ; Zambuzzi, Willian Fernando [2, 3] ; Bramante, Clovis Monteiro [4] ; Cestari, Tania Mari [5] ; Taga, Rumio [5] ; Sader, Marcia [6] ; de Almeida Soares, Gloria Dulce [6] ; Granjeiro, Jose Mauro [7, 2, 3]
Total Authors: 8
[1] Univ Grande Rio, Dept Endodont, BR-25071202 Duque De Caxias, RJ - Brazil
[2] Standardizat & Ind Qual INMETRO, Projects Div, Natl Inst Metrol, Rio De Janeiro - Brazil
[3] Univ Hosp Antonio Pedro, Cell therapy Ctr, Niteroi, RJ - Brazil
[4] Univ Sao Paulo, Dept Endodont, Bauru Dent Sch, Sao Paulo - Brazil
[5] Univ Sao Paulo, Dept Biol Sci, Bauru Dent Sch, Sao Paulo - Brazil
[6] Univ Fed Rio de Janeiro, Rio De Janeiro - Brazil
[7] Univ Fed Fluminense, Dept Cell & Mol Biol, Inst Biol, UFF, BR-24020150 Centro Niteroi, RJ - Brazil
Total Affiliations: 7
Document type: Journal article
Web of Science Citations: 5

Our purpose was to evaluate the osteoconduction potential of mixed bovine bone (MBB) xenografts as an alternative for bone grafting of critical-size defects in the calvaria of rats. After surgery, in the time intervals of 1, 3, 6, and 9 months, rats were killed and their skulls collected, radiographed and histologically prepared for analysis. The data obtained from histological analysis reported that the particles of MBB did not promote an intense immunological response, evidencing its biocompatibility in rats. Our results clearly showed the interesting evidence that MBB was not completely reabsorbed at 9 months while a small amount of newly formed bone was deposited by osteoprogenitor cells bordering the defect. However, this discrete bone-forming stimulation was unable to regenerate the bone defect. Overall, our results suggest that the properties of MBB are not suitable for stimulating intense bone regeneration in critical bone defects in rats. (AU)

FAPESP's process: 99/10655-5 - José Mauro Granjeiro | Faculdade de Odontologia de Bauru/USP - Brazil
Grantee:Mari Cleide Sogayar
Support type: Research Grants - Visiting Researcher Grant - Brazil
FAPESP's process: 01/10707-7 - Molecular bases of the control of cell proliferation and origin of neoplasms in the genomic and proteomic era
Grantee:Mari Cleide Sogayar
Support type: Research Projects - Thematic Grants