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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oroidin Inhibits the Activity of the Multidrug Resistance Target Pdr5p from Yeast Plasma Membranes

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Author(s):
da Silva, Fernanda R. [1] ; Tessis, Ana Claudia [2] ; Ferreira, Patricia F. [1] ; Rangel, Luciana P. [1] ; Garcia-Gomes, Aline S. [1] ; Pereira, Fabio R. [3] ; Berlinck, Roberto G. S. [3] ; Muricy, Guilherme [4] ; Ferreira-Pereira, Antonio [1]
Total Authors: 9
Affiliation:
[1] Univ Fed Rio de Janeiro, IMPPG, Dept Microbiol Geral, Lab Bioquim Microbiana, BR-21941590 Rio De Janeiro - Brazil
[2] Inst Fed Rio de Janeiro, BR-20270021 Rio De Janeiro - Brazil
[3] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[4] Univ Fed Rio de Janeiro, Museu Nacl, BR-20940040 Rio De Janeiro - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Natural Products; v. 74, n. 2, p. 279-282, FEB 2011.
Web of Science Citations: 13
Abstract

Oroidin was isolated from the marine sponge Agelas sventres and inhibited the activity and function of Pdr5p, an enzyme responsible for the multidrug resistance phenotype in Saccharomyces cerevisiae. This compound may help in the development of new drugs that reverse this dangerous phenotype of pathogenic yeast and fungi. (AU)

FAPESP's process: 05/60175-2 - Discovery and development of potential chemotherapeutic agents based on marine invertebrates and associated micro-organisms
Grantee:Roberto Gomes de Souza Berlinck
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants