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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Optimization of in situ derivatization SPME by experimental design for GC-MS multi-residue analysis of pharmaceutical drugs in wastewater

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Author(s):
Feitosa de Lima Gomes, Paulo Clairmont [1] ; Barletta, Juliana Yamashita [1] ; Domingues Nazario, Carlos Eduardo [1] ; Santos-Neto, Alvaro Jose [1] ; Von Wolff, Marya Anne [2] ; Reganhan Coneglian, Cassiana Maria [2] ; Umbuzeiro, Gisela Aragao [2] ; Lancas, Fernando Mauro [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Inst Chem Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Estadual Campinas, Fac Technol, Limeira, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF SEPARATION SCIENCE; v. 34, n. 4, p. 436-445, FEB 2011.
Web of Science Citations: 20
Abstract

This paper presents the development of a procedure, which enables the analysis of nine pharmaceutical drugs in wastewater using gas chromatography-mass spectrometry (GC-MS) associated with solid-phase microextraction (SPME) for the sample preparation. Experimental design was applied to optimize the in situ derivatization and the SPME extraction conditions. Ethyl chloroformate (ECF) was employed as derivatizing agent and polydimethylsiloxane-divinylbenzene (PDMS-DVB) as the SPME fiber coating. A fractional factorial design was used to evaluate the main factors for the in situ derivatization and SPME extraction. Thereafter, a Doehlert matrix design was applied to find out the best experimental conditions. The method presented a linear range from 0.5 to 10 mu g/L, and the intraday and interday precision were lower than 16%. Applicability of the method was verified from real influent and effluent samples of a wastewater treatment plant, as well as from samples of an industry wastewater and a river. (AU)

FAPESP's process: 05/59360-0 - Miniaturization of analytical instrumentation for separation techniques: sample preparation and printing of result
Grantee:Fernando Mauro Lanças
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 07/03844-4 - Simultaneous analysis of multi-residue antibiotics in water and sediments by headspace bar sorptive extraction with in situ derivatization coupled to GC / MS
Grantee:Paulo Clairmont Feitosa de Lima Gomes
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)