Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer

Author(s)

Gomes, Paulo C. ^[1] ; de Souza, Bibiana M. ^[1] ; Dias, Nathalia B. ^[1] ; Cesar-Tognoli, Lilian M. M. ^[1] ; Silva-Filho, Luiz C. ^[2] ; Tormena, Claudio F. ^[3] ; Rittner, Roberto ^[3] ; Richardson, Michael ^[4] ; Cordeiro, Marta N. ^[4] ; Palma, Mario S. ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Dept Biol CEIS, Inst Biosci, Sao Paulo - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Chem, Fac Sci, Sao Paulo - Brazil

^[3] Univ Estadual Campinas, Inst Chem, Sao Paulo - Brazil

^[4] Ezequiel Dias Fdn FUNED, Ctr Res & Dev, Belo Horizonte, MG - Brazil

• Document type: Journal article
• Source: Toxicon; v. 57, n. 2, p. 266-274, FEB 2011.
• Web of Science Citations: 9

Abstract

Nigriventrine was isolated from the ``armed{''} spider Phoneutria nigriventer, in which it constitutes about 0.4% of the total venom content. Its structure was determined to be {[}1,1`-(1-hydroxyhydrazine-1,2-diyl)bis(oxy)bis(4-hydroxy-2,6-dioxopipe ridine-4 carboxylic acid)] by NMR, HR-ES/IMS and MS/MS methods. The intracerebroventricular application of nigriventrine in rat brain, followed by the detection of c-Fos protein expression, indicated that the compound was neuroactive in the motor cortex, sensory cortex, piriform cortex, median preoptic nucleus, dorsal endopiriform nucleus, lateral septal nucleus and hippocampus of rat brain. Nigriventrine causes convulsions in rats, even when peripherally applied. (c) 2010 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 04/07942-2 - Bioprospetion of the Brazilian arthropods fauna searching for leader drugs for rational development of novel pharmaceuticals and pesticides
• Grantee: Mario Sergio Palma
• Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants