Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania

Author(s):Show less -

Valvassori, Samira S. ^{[1, 2]} ; Elias, Guilherme ^{[1, 2]} ; de Souza, Bruna ^{[1, 2]} ; Petronilho, Fabricia ^{[1, 2]} ; Dal-Pizzol, Felipe ^{[1, 2]} ; Kapczinski, Flavio ^{[1, 3, 4]} ; Trzesniak, Clarissa ^{[5, 1]} ; Tumas, Vitor ^{[5, 1]} ; Dursun, Serdar ^{[1, 6]} ; Nisihara Chagas, Marcos Hortes ^{[5, 1]} ; Hallak, Jaime E. C. ^{[5, 1]} ; Zuardi, Antonio W. ^{[5, 1]} ; Quevedo, Joao ^{[1, 2]} ; Crippa, Jose A. S. ^{[5, 1]}

Affiliation

^[1] CNPq, INCT Translat Med, Campinas, SP - Brazil

^[2] Univ Extremo Sul Catarinense, Lab Neurociencias, Programa Posgrad Ciencias Saude, Unidade Acad Ciencias Saude, Criciuma, SC - Brazil

^[3] Hosp Clin Porto Alegre, Bipolar Disorders Programme, Porto Alegre, RS - Brazil

^[4] Hosp Clin Porto Alegre, Lab Mol Psychiat, Ctr Pesquisas, Porto Alegre, RS - Brazil

^[5] Univ Sao Paulo, Dept Behav Neurosci, Div Psychiat, Ribeirao Preto Med Sch, BR-14049 Ribeirao Preto, SP - Brazil

^[6] Univ Alberta, Dept Psychiat, Edmonton, AB - Canada

• Document type: Journal article
• Source: JOURNAL OF PSYCHOPHARMACOLOGY; v. 25, n. 2, p. 274-279, FEB 2011.
• Web of Science Citations: 25

Abstract

Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by D-amphetamine (D-AMPH). In the first model (reversal treatment), rats received saline or D-AMPH (2 mg/kg) once daily intraperitoneal (i.p.) for 14 days, and from the 8th to the 14th day, they were treated with saline or CBD (15, 30 or 60 mg/kg) i.p. twice a day. In the second model (prevention treatment), rats were pretreated with saline or CBD (15, 30, or 60 mg/kg) regime i.p. twice a day, and from the 8th to the 14th day, they also received saline or D-AMPH i.p. once daily. In the hippocampus CBD (15 mg/kg) reversed the D-AMPH-induced damage and increased (30 mg/kg) brain-derived neurotrophic factor (BDNF) expression. In the second experiment, CBD (30 or 60 mg/kg) prevented the D-AMPH-induced formation of carbonyl group in the prefrontal cortex. In the hippocampus and striatum the D-AMPH-induced damage was prevented by CBD (15, 30 or 60 mg/kg). At both treatments CBD did not present any effect against D-AMPH-induced hyperactivity. In conclusion, we could not observe effects on locomotion, but CBD protect against D-AMPH-induced oxidative protein damage and increased BDNF levels in the reversal model and these effects vary depending on the brain regions evaluated and doses of CBD administered. (AU)

• FAPESP's process: 02/13197-2 - Participation of glutamate and nitric oxide on the pathophysiology of neuropsychiatry disorders
• Grantee: Francisco Silveira Guimaraes
• Support Opportunities: Research Projects - Thematic Grants