| Full text | |
| Author(s): |
Perico, Cintia de Azevedo-Marques
[1, 2]
;
Duran, Fabio L. S.
[1, 2]
;
Zanetti, Marcus V.
[1, 2]
;
Santos, Luciana C.
[1, 2]
;
Murray, Robin M.
[3]
;
Scazufca, Marcia
[1, 2]
;
Menezes, Paulo R.
[4]
;
Busatto, Geraldo F.
[1, 2]
;
Schaufelberger, Maristela S.
[1, 2]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med, Dept Psychiat, Lab Psychiat Neuroimaging LIM 21, BR-05403903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Inst Psychiat, Lab Psychiat Neuroimaging LIM 21, BR-05403903 Sao Paulo - Brazil
[3] Kings Coll London, Inst Psychiat, Dept Psychiat, London WC2R 2LS - England
[4] Univ Sao Paulo, Fac Med, Dept Prevent Med, BR-05403903 Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | BIPOLAR DISORDERS; v. 13, n. 1, p. 28-40, FEB 2011. |
| Web of Science Citations: | 26 |
| Abstract | |
Objectives: Many morphometric magnetic resonance imaging (MRI) studies that have investigated the presence of gray matter (GM) volume abnormalities associated with the diagnosis of bipolar disorder (BD) have reported conflicting findings. None of these studies has compared patients with recent-onset psychotic BD with asymptomatic controls selected from exactly the same environment using epidemiological methods, or has directly contrasted BD patients against subjects with first-onset psychotic major depressive disorder (MDD). We examined structural brain differences between (i) BD (type I) subjects and MDD subjects with psychotic features in their first contact with the healthcare system in Brazil, and (ii) these two mood disorder groups relative to a sample of geographically matched asymptomatic controls. Methods: A total of 26 BD subjects, 20 subjects with MDD, and 94 healthy controls were examined using either of two identical MRI scanners and acquisition protocols. Diagnoses were based on DSM-IV criteria and confirmed one year after brain scanning. Image processing was conducted using voxel-based morphometry. Results: The BD group showed increased volume of the right dorsal anterior cingulate cortex relative to controls, while the MDD subjects exhibited bilateral foci GM deficits in the dorsolateral prefrontal cortex (p < 0.05, corrected for multiple comparisons). Direct comparison between BD and MDD patients showed a focus of GM reduction in the right-sided dorsolateral prefrontal cortex (p < 0.05, corrected for multiple comparisons) and a trend (p < 0.10, corrected) toward left-sided GM deficits in the dorsolateral prefrontal cortex of MDD patients. When analyses were repeated with scanner site as a confounding covariate the finding of increased right anterior cingulate volumes in BD patients relative to controls remained statistically significant (p = 0.01, corrected for multiple comparisons). Conclusions: These findings reinforce the view that there are important pathophysiological distinctions between BD and MDD, and indicate that subtle dorsal anterior cingulate abnormalities may be relevant to the pathophysiology of BD. (AU) | |