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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

L-histidine induces state-dependent memory deficit in mice mediated by H-1 receptor

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Author(s):
Gianlorenco, Anna Carolyna [1] ; Canto-de-Souza, Azair [2] ; Mattioli, Rosana [1]
Total Authors: 3
Affiliation:
[1] Fed Univ Sao Carlos UFSCar, Dept Physiotherapy, Neurosci Lab, Sao Carlos, SP - Brazil
[2] Fed Univ Sao Carlos UFSCar, Dept Psychol, Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 35, n. 1, p. 91-95, JAN 15 2011.
Web of Science Citations: 10
Abstract

This study investigated the role of H(1) receptor in the state-dependent memory deficit induced by L-histidine (LH) in mice using Trial 1/2 protocol in the elevated plus-maze (EPM). The test was performed for two consecutive days: Trial 1 (T1) and Trial 2 (T2). Before both trials, mice received a combined injection i.p. of saline + saline (SAL/SAL), 500 mg/kg L-histidine + saline (LH/SAL), 500 mg/kg L-histidine + 16 mg/kg chlorpheniramine (LH/CPA) or saline + 16 mg/kg chlorpheniramine (SAL/CPA). The trials were performed in the EPM 10 min after the last injection. Each animal was placed in the center of the maze facing the open arm and had five minutes to explore it. On both days, test sessions were videotaped. The behavioral measures were scored from videotape. Data were analyzed based on Analysis of Variance (ANOVA) and the Fisher's LSD test. The data showed no effects on anxiety since there was no difference between the SAL/SAL and the other groups in Trial 1, respectively, open arm entries (OAE), open arm time (OAT) and their percentages (%OAE and %OAT). During Trial 2, OAE, OAT, %OAE and %OAT were reduced in mice treated with SAL/SAL, LH/CPA and SAL/CPA, while the group LH/SAL did not show any difference in these measures. No significant changes were observed in enclosed arm entries (EAE), an EPM index of general exploratory activity. Thus, it can be suggested that LH induces emotional memory deficit and the treatment with chlorpheniramine was able to revert this effect, suggesting this action of LH was mediated by the H1 receptor. (C) 2010 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 08/01526-8 - Effects of chronic treatment with chlorpheniramine in mice submitted and re-exposed to the elevated Pluz-Maze
Grantee:Anna Carolyna Lepesteur Gianlorenço
Support Opportunities: Scholarships in Brazil - Master