Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Healing of displaced condylar process fracture in rats submitted to protein undernutrition

Full text
Author(s):
Rodrigues, Lucimar [1] ; Correa, Luciana [2] ; Luz, Joao Gualberto C. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Dept Oral & Maxillofacial Surg, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Gen Pathol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY; v. 39, n. 1, p. 73-78, JAN 2011.
Web of Science Citations: 13
Abstract

Introduction: This study evaluated the healing of mandibular condylar fracture in rats submitted to experimental and protein undernutrition (8% of protein) by means of histological analysis. Material: Forty-five adult Wistar rats were divided into three groups of 15 animals: a fracture group, who were submitted to condylar fracture with no changes in diet; an undernourished fracture group, who were submitted to a low protein diet and condylar fracture: an undernourished group, kept until the end of experiment, without condylar fracture. Displaced fractures of the right condyle were created under general anaesthesia. The histological study comprised fracture site and temporomandibular joint evaluations. Results: The undernourished fracture group showed significant weight loss. There was a marked decrease in the values of serum proteins and albumin in the undernourished fracture group. Histological analysis showed that protein undernutrition lead to atrophy of the condylar fibrocartilage. Fractures in undernutrition presented a delay in callus formation due to more extensive devitalized bone areas, and after 3 months there were still bone formation areas, while fibrous ankylosis occurred in the articular space. Conclusion: It was concluded that mandibular condyle fractures in rats with protein undernutrition had impaired callus formation, as well as fibrous ankylosis into the temporomandibular joint. (C) 2010 European Association for Cranio-Maxillo-Facial Surgery. (AU)

FAPESP's process: 05/01891-0 - Local and systemic alterations of rats (Rattus norvegicus) submitted to condylar fracture: influence of nutritional factors on bone repair
Grantee:Luciana Corrêa
Support Opportunities: Regular Research Grants