Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Involvement of the AT(1) receptor in the venoconstriction induced by angiotensin II in both the inferior vena cava and femoral vein

Full text
Author(s):
da Silva, Osmar Gomes [1] ; Rossignoli, Patricia de Souza [2, 3] ; Carrillo-Sepulveda, Maria Alicia [4] ; Morais Barreto-Chaves, Maria Luiza [4] ; Chies, Agnaldo Bruno [2]
Total Authors: 5
Affiliation:
[1] Univ Marilia, Fac Pharm & Biochem, Sao Paulo - Brazil
[2] Fac Med Marilia, Pharmacol Lab, BR-17519030 Marilia, SP - Brazil
[3] Biosci Inst Botucatu, Dept Pharmacol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Anat, Inst Biomed Sci, Lab Cell Biol & Funct Anat, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Peptides; v. 32, n. 1, p. 112-117, JAN 2011.
Web of Science Citations: 1
Abstract

Although angiotensin II-induced venoconstriction has been demonstrated in the rat vena cava and femoral vein, the angiotensin II receptor subtypes (AT(1) or AT(2)) that mediate this phenomenon have not been precisely characterized. Therefore, the present study aimed to characterize the pharmacological receptors involved in the angiotensin II-induced constriction of rat venae cavae and femoral veins, as well as the opposing effects exerted by locally produced prostanoids and NO upon induction of these vasomotor responses. The obtained results suggest that both AT(1) and AT(2) angiotensin II receptors are expressed in both veins. Angiotensin II concentration-response curves were shifted toward the right by losartan but not by PD 123319 in both the vena cava and femoral vein. Moreover, it was observed that both 10(-5) M indomethacin and 10(-4) M L-NAME improve the angiotensin II responses in the vena cava and femoral vein. In conclusion, in the rat vena cava and femoral vein, angiotensin II stimulates AT(1) but not AT(2) to induce venoconstriction, which is blunted by vasodilator prostanoids and NO. (C) 2010 Elsevier Inc. All rights reserved. (AU)