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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinical and genetic risk factors for moderate hyperbilirubinemia in Brazilian newborn infants

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Author(s):
Mezzacappa, M. A. [1] ; Facchini, F. P. [1] ; Pinto, A. C. [1] ; Cassone, A. E. L. [1] ; Souza, D. S. ; Bezerra, M. A. C. ; Albuquerque, D. M. [2] ; Saad, S. T. O. [2] ; Costa, F. F. [2]
Total Authors: 9
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Dept Pediat, Sch Med Sci, Div Neonatol, BR-13083881 Sao Paulo - Brazil
[2] Univ Estadual Campinas, UNICAMP, Hematol & Hemotherapy Ctr, Dept Internal Med, Sch Med Sci, Hemoctr, BR-13083881 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Perinatology; v. 30, n. 12, p. 819-826, DEC 2010.
Web of Science Citations: 10
Abstract

Objective: To identify clinical and genetic risk factors for moderate hyperbilirubinemia during the first week of life. Study Design: Using univariate and multivariate multiple regression analyses, the RR for clinical factors, the African variant of glucose-6-phosphate dehydrogenase (G6PD) deficiency (G202A/A376G), and (TA)(n) UGT1A1 polymorphisms were established in a cohort of 608 Brazilian newborn infants. Hyperbilirubinemia was monitored until 134.5 +/- 49.8 h of life (IQR, 111.0 to 156.7). The dependent variable was total bilirubinemia (TB) >= 12.9 mg per 100 ml estimated by transcutaneous or plasma bilirubin measurements. Result: The African variant of G6PD deficiency and (TA)(7)/(TA)(7) and (TA)(7)/(TA)(8) polymorphisms present in 6.1 and 12.0% of newborns, respectively, were not risk factors for moderate hyperbilirubinemia. Coexpression of G6DP deficiency and UGT1A1 polymorphisms occurred in 0.49% of the subjects. Independent clinical predictors for TB >= 12.9mg per 100 ml were gestational age <38 weeks and reference curve percentiles >P40th. Conclusion: In this study, G6PD deficiency and UGT1A1 gene promoter polymorphisms were not risk factors for moderate hyperbilirubinemia. Genetic factors may vary considerably in importance among different populations. Journal of Perinatology (2010) 30, 819-826; doi: 10.1038/jp.2010.48; published online 8 April 2010 (AU)