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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Use of Experimental Design for the Optimization of the Production of New Secondary Metabolites by Two Penicillium Species

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Author(s):
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Pimenta, Eli F. [1] ; Vita-Marques, Aline M. [1] ; Tininis, Aristeu [2] ; Seleghim, Mirna H. R. [3] ; Sette, Lara D. [4] ; Veloso, Katyuscya [5] ; Ferreira, Antonio G. [5] ; Williams, David E. [6, 7] ; Patrick, Brian O. [6, 7] ; Dalisay, Doralyn S. [6, 7] ; Andersen, Raymond J. [6, 7] ; Berlinck, Roberto G. S. [1]
Total Authors: 12
Affiliation:
[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[2] Inst Fed Educ Ciencia & Tecnol, BR-14169263 Sertaozinho, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Ecol & Biol Evolut, BR-13560 Sao Carlos, SP - Brazil
[4] Univ Estadual Campinas, Div Recursos Microbianos, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, BR-13083970 Campinas, SP - Brazil
[5] Univ Fed Sao Carlos, Dept Quim, BR-13560 Sao Carlos, SP - Brazil
[6] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1 - Canada
[7] Univ British Columbia, Dept Earth & Ocean Sci, Vancouver, BC V6T 1Z1 - Canada
Total Affiliations: 7
Document type: Journal article
Source: Journal of Natural Products; v. 73, n. 11, p. 1821-1832, NOV 2010.
Web of Science Citations: 32
Abstract

A fractional factorial design approach has been used to enhance secondary metabolite production by two Penicillium strains. The method was initially used to improve the production of bioactive extracts as a whole and subsequently to optimize the production of particular bioactive metabolites. Enhancements of over 500% in secondary metabolite production were observed for both P. oxalicum and P. citrinum. Two new alkaloids, citrinalins A (5) and B (6), were isolated and identified from P. citrinum cultures optimized for production of minor metabolites. (AU)

FAPESP's process: 05/60175-2 - Discovery and development of potential chemotherapeutic agents based on marine invertebrates and associated micro-organisms
Grantee:Roberto Gomes de Souza Berlinck
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants