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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy

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Author(s):
Valladao, M. L. [1, 2] ; Scarpelli, K. C. [2] ; Metze, K. [1]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, Fac Ciencias Med, Campinas, SP - Brazil
[2] Ctr Controle Zoonoses, Taubate, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Arquivo Brasileiro de Medicina Veterinária e Zootecnia; v. 62, n. 5, p. 1086-1093, OCT 2010.
Web of Science Citations: 3
Abstract

The clinical utility of a life quality score during vincristine chemotherapy of dogs with canine transmissible venereal tumor (CTVT) was investigated using 93 tumor-bearing dogs in this prospective study. At diagnosis, clinical data and the performance status were evaluated according to a modified Karnofsky score (CKS) adapted for dogs. The animals were treated with vincristine sulphate (0.025mg/kg) at weekly intervals until the tumor had macroscopically disappeared. The time until the first adverse event and death were recorded. In a pilot study, CKS revealed a high inter-observer concordance (kappa=0.735; weighted kappa=0.835). CKS permitted a detailed monitoring of adverse effects during therapy. Cox regressions showed that low performance score and reduced body weight were independent predictive factors for death during chemotherapy. The modified Karnofsky performance score is a simple and reproducible clinical instrument, able to estimate patient outcome after treatment of CTVT. (AU)