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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor

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Author(s):
dos Santos, Daniela Pereira [1] ; Bergamini, Marcio Fernando [2] ; Boldrin Zanoni, Maria Valnice [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo State, Inst Chem, UNESP, BR-14801970 Araraquara, SP - Brazil
[2] UFPR, Ctr Politecn, Setor Ciencias Exatas, Dept Quim, BR-81531990 Curitiba, Parana - Brazil
Total Affiliations: 2
Document type: Journal article
Source: International Journal of Electrochemical Science; v. 5, n. 10, p. 1399-1410, OCT 2010.
Web of Science Citations: 7
Abstract

The poly-L-glutamic acid (PGA), was used a biodegradable polymers as conjugated to doxorubicin (DXR) and also in the modification glassy carbon electrode. The interaction operate via terminal amino groups of the drug and the side chain carboxyl groups of branched PGA film and it is the base to develop a simple voltammetric sensor for the determination of doxorubicin in human urine. The preconcentration of DXR on the modified electrode occurs under open circuit and studied by the methods of square wave voltammetry to monitor the drug. Standard curves were linear over the concentration range of 2.20 - 44.5 mu mol L(-1) giving a detection limit of 0.45 mu mol L(-1) show that the proposed sensor is suitable for doxorubicin determination in real samples. (AU)