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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association of complement factor H Y402H polymorphism and age-related macular degeneration in Brazilian patients

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Author(s):
Teixeira, Anderson G. [1] ; Silva, Aldacilene S. [2] ; Lin, Fabio L. H. [2] ; Velletri, Roberta [1] ; Bavia, Lorena [2] ; Belfort, Jr., Rubens [1] ; Isaac, Lourdes [2]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo, Dept Ophthalmol, BR-04023062 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ACTA OPHTHALMOLOGICA; v. 88, n. 5, p. E165-E169, AUG 2010.
Web of Science Citations: 9
Abstract

Purpose: The aim of this study was investigate the association between complement Factor H polymorphism (Y402H) and age-related macular degeneration (AMD) in Brazilian patients. Methods: Patients with AMD aged 50 or more and age-matched healthy controls were enrolled in the study. Genomic DNA was isolated from leucocytes of patients and controls; the Y402H polymorphism of complement Factor H gene (CFH) was determined by polymerase chain reaction directed sequencing. Results: The frequency of 1277C allele of Factor H was 56.30% in patients with AMD compared with 36.51% in controls (p-value = 0.001). The genotypic distribution differed significantly between the two groups (1277CC 36.98%, 1277CT 38.65% and 1277TT 24.37% for AMD group; 1277CC 13.16%, 1277CT 46.71% and 1277TT 40.13% for controls, p-value = 0.001). The odds ratio for patients with AMD carrying only one 1277C allele was 1.36 and for those carrying two 1277C alleles was 4.63, when compared to the control group. Conclusions: These results suggest the Y402H polymorphism of CFH is a risk factor to the development of AMD in Brazilian patients. This is in accordance with findings from the majority of previous study population in Europe and North American. (AU)