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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Propolis Immunomodulatory Action In Vivo on Toll-Like Receptors 2 and 4 Expression and on Pro-Inflammatory Cytokines Production in Mice

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Author(s):
Orsatti, C. L. [1] ; Missima, F. [1] ; Pagliarone, A. C. [1] ; Bachiega, T. F. [1] ; Bufalo, M. C. [1] ; Araujo, Jr., J. P. [1] ; Sforcin, J. M. [1]
Total Authors: 7
Affiliation:
[1] UNESP, Dept Microbiol & Immunol, Biosci Inst, BR-18618000 Jaboticabal, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Phytotherapy Research; v. 24, n. 8, p. 1141-1146, AUG 2010.
Web of Science Citations: 51
Abstract

Propolis is a bee product and its immunomodulatory action has been the subject of intense investigation lately. The recent discovery and characterization of the family of Toll-like receptors (TLR) have triggered a great deal of interest in the field of innate immunity due to their crucial role in microbial recognition and development of the adaptive immune response. This work aimed to evaluate propolis's effect on TLR-2 and TLR-4 expression and on the production of pro-inflammatory cytokines (IL-1 beta and IL-6). Male BALB/c mice were treated with propolis (200 mg/kg) for three consecutive days, and TLR-2 and TLR-4 expression as well as IL-1 beta and IL-6 production were assessed in peritoneal macrophages and spleen cells. Basal IL-1 beta production and TLR-2 and TLR-4 expression were increased in peritoneal macrophages of propolis-treated mice. TLR-2 and TLR-4 expression and IL-1 beta and IL-6 production were also upregulated in the spleen cells of propolis-treated mice. One may conclude that propolis activated the initial steps of the immune response by upregulating TLRs expression and the production of pro-inflammatory cytokines in mice, modulating the mechanisms of the innate immunity. Copyright (C) 2009 John Wiley \& Sons, Ltd. (AU)