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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cardiovascular response during trigeminal ganglion compression for trigeminal neuralgia according to the use of local anesthetics

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Author(s):
Tibano, Adriana Tanaka ; de Siqueira, Silvia Regina D. T. [1, 2] ; Marinho da Nobrega, Jose Claudio [3] ; Teixeira, Manoel Jacobsen [4]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Med, Escola Artes Ciencias & Humanidades, Hosp Clin, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Orofacial Pain Grp, Hosp Clin, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Funct Neurosurg Div, Neurol Dept, Hosp Clin, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Pain Ctr, Neurol Dept, Hosp Clin, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ACTA NEUROCHIRURGICA; v. 152, n. 8, p. 1347-1351, AUG 2010.
Web of Science Citations: 3
Abstract

There are controversies about the use of local anesthetics during balloon compression for trigeminal neuralgia (TN) as a protective factor for cardiovascular events. The objective of this study was to investigate cardiovascular parameters (blood pressure and heart rate {[}HR]) of patients that underwent trigeminal balloon compression with local anesthetics compared to a control group (placebo). This is a randomized controlled study; 55 patients were randomized into two groups: study (deep sedation and trigeminal block with 0.8-mL lidocaine 2%) and control group (deep sedation and trigeminal injection of 0.8-mL saline). Blood pressure and HR were measured in five distinct moments: preoperative, during puncture for local anesthesia/placebo, during puncture with the catheter, during balloon compression, and final evaluation. Statistical analysis was performed with Pearson's chi (2) and McNemar tests and the analysis of variance for repetitive measures. The means of systolic and diastolic blood pressures (SBP and DBP, respectively) were higher in the control group when compared to the study group at the evaluation during puncture with the catheter (p < 0.001) and balloon compression (p < 0.001 and p = 0.018 for DBP and SBP, respectively). There was an increase in the HR in the control group during the procedure (p = 0.017). The use of local anesthetics during the trigeminal balloon compression for TN can have a preventive role for the risk of cardiovascular events. (AU)

FAPESP's process: 08/05078-0 - Hemodynamic abnormalities during the compression of the Gasserian ganglion with a balloon with or without local anesthetics
Grantee:Silvia Regina Dowgan Tesseroli de Siqueira
Support Opportunities: Regular Research Grants