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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Treadmill running protects spinal cord contusion from secondary degeneration

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Author(s):
Ramos Andrade, Michele Schultz [1] ; Mendonca, Lucio Mario [1] ; Chadi, Gerson [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Sch Med, Neuroregenerat Ctr, Expt Neurol Div, Dept Neurol, BR-01246903 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Brain Research; v. 1346, p. 266-278, JUL 30 2010.
Web of Science Citations: 12
Abstract

It is known that physical activity triggers changes in the central nervous system Adult rats, trained on treadmills for 4 weeks, and a group of sedentary rats was submitted to contuse moderate spinal cord injury A group of sedentary rats was submitted to a sham operation The trained group continued running on treadmill after lesion for 4 weeks Motor behavior evaluated by BBB score was smaller in the sedentary group compared to the trained rats by 7 days after lesion Computerized activity monitor showed clear-cut differences in spontaneous motor parameters in trained rats only before lesion After surgery, sedentary rats showed changes in motor parameters but not in later periods of analysis Animals were euthanized by 28 days after surgery, and their spinal cords were processed for Nissl staining and immunohistochemistry The number of the remaining neurons and the lesion areal and lesion volume fractions were obtained by stereological method The number of the remaining neurons did not change after training Lesion volume and lesion areal fraction per section were smaller in the trained group Lesion index was more pronounced in the sedentary group Microdensitometric image analysis demonstrated a microglial reaction, astroglial activation, and glial FGF-2 production more pronounced in the spinal cord of sedentary animals GAP-43 was higher in caudal levels of contusion in the sedentary group In conclusion, treadmill running may favor a better functional recovery in the acute period after spinal cord lesion and wound repair processes leading to neuroprotection (C) 2010 Elsevier B V All rights reserved (AU)

FAPESP's process: 09/14214-7 - Analysis of the participation of neuronal and non-neuronal cells on Amyothophic Lateral Sclerosis in human SOD1 mutant mice by using laser microdissection and real time PCR techniques
Grantee:Gabriela Pintar de Oliveira
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)