Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Family-based association study for bipolar affective disorder

Full text
Author(s):
Secolin, Rodrigo ; Banzato, Claudio E. M. [1] ; Oliveira, Maria C. M. [1] ; Bittar, Maria F. R. ; Santos, Marilza L. ; Dalgalarrondo, Paulo [1] ; Lopes-Cendes, Iscia [2]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Dept Med Psychol & Psychiat, BR-13084971 Campinas, SP - Brazil
[2] Univ Estadual Campinas, FCM, Dept Med Genet, BR-13084971 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PSYCHIATRIC GENETICS; v. 20, n. 3, p. 126-129, JUN 2010.
Web of Science Citations: 5
Abstract

In this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio = 2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences. Psychiatr Genet 20:126-129 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams \& Wilkins. (AU)