| Full text | |
| Author(s): |
Cerda, Alvaro
[1]
;
Genvigir, Fabiana D. V.
[1]
;
Arazi, Simone S.
[1]
;
Hirata, Mario H.
[1]
;
Dorea, Egidio L.
[2]
;
Bernik, Marcia M. S.
[2]
;
Bertolami, Marcelo C.
[3]
;
Faludi, Andre A.
[3]
;
Hirata, Rosario D. C.
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Dept Clin & Toxicol Anal, Sch Pharmaceut Sci, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Univ Hosp, BR-05508900 Sao Paulo - Brazil
[3] Dante Pazzanese Inst Cardiol, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Clinica Chimica Acta; v. 411, n. 9-10, p. 631-637, MAY 2 2010. |
| Web of Science Citations: | 19 |
| Abstract | |
Background: The SR-BI is a key component on the cholesterol metabolism. Polymorphisms in the SR-BI gene (SCARB1) were related with variations on plasma lipoprotein profile and other risk factors for cardiovascular disease. We tested the relationship of 3 SCARB1 single nucleotide polymorphisms (SNPs) with hypercholesterolemia in a Brazilian population and whether these variants can influence lipid-lowering response to atorvastatin. Methods: c.4G>A, c.726+54C>T and c.1050C>T SNPs and serum concentrations of lipid and apolipoproteins were evaluated in 147 hypercholesterolemic (HC) and 185 normolipidemic (NL) unrelated Brazilian subjects. HC patients were treated with atorvastatin (10 mg/day/4 weeks). Results: Frequencies of SCARB1 polymorphisms were similar between the HC and NL groups (p>0.05). The T allele for c.726+54C>T was associated with higher LDL-c in NL and with higher apoB and apoB/apoAI in HC (p<0.05). HC individuals carrying c.1050C allele carriers (CC and CT genotypes) had lower change of total cholesterol, LDL-c, apoB and apoB/apoAI ratio (p<0.05) than the TT genotype carriers in response to atorvastatin. Conclusion: The SCARB1 polymorphisms are related with variations in serum lipids in the Brazilian population and c.1050C>T SNP is associated with lipid-lowering atorvastatin response. (C) 2010 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 06/06196-0 - Pharmacogenomics study: effects of hypolipidemic drugs on gene expression of transcription factors involved in cholesterol regulation |
| Grantee: | Rosario Dominguez Crespo Hirata |
| Support Opportunities: | Regular Research Grants |