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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Reactivity of p53 protein in canine transmissible venereal tumor

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Author(s):
Moro, J. V. [1] ; Tinucci-Costa, M. [1] ; Silveira, A. C. T. [1] ; Gerardi, D. G. [1] ; Alessi, A. C. [1]
Total Authors: 5
Affiliation:
[1] UNESP, Fac Ciencias Agr & Vet, BR-14884900 Jaboticabal, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Arquivo Brasileiro de Medicina Veterinária e Zootecnia; v. 62, n. 2, p. 318-323, APR 2010.
Web of Science Citations: 8
Abstract

The expression of p53 protein was evaluated in canine transmissible venereal tumor (CTVT), as following: natural occurrence (n=8); resistant to chemotherapy (n=4); and allogeneic transplanted in progression (n=8), stable (n=8), and regression (n=8)stages. The collected specimens were submitted to GM1 immunohistochemical reaction. Results showed a mean percentage of immunomarked cells around 18.6% in CTVT of natural occurrence, 23.8% in CTVT resistant to chemotherapy, 22.9% in allogeneic transplanted CTVT in both progression and stable stages, and 35.8% in transplanted CTVT in regression stage. The results suggest that there is a functional abnormality in p53 gene and its products in the studied tumors; although, it is not possible to correlate the percentage of cells marked by p53 and a prognosis. (AU)