| Full text | |
| Author(s): Show less - |
Rossatto Oki, Glaucia Celeste
[1]
;
Zantut-Wittmann, Denise Engelbrecht
[2]
;
Santos, Allan de Oliveira
[1]
;
Guariento, Maria Helena
[3]
;
Tambascia, Marcos Antonio
[2]
;
de Almeida, Eros Antonio
[3]
;
Amorim, Barbara Juarez
[1]
;
Lopes Lima, Mariana Cunha
[1]
;
Sa Camargo Etchebehere, Elba Cristina
[1]
;
Camargo, Edwaldo Eduardo
[1]
;
Ramos, Celso Dario
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Estadual Campinas, Sch Med Sci, Div Nucl Med, Dept Radiol, BR-13083887 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Dept Internal Med, Div Endocrinol, BR-13083887 Campinas, SP - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, Dept Internal Med, Div Internal Med, BR-13083887 Campinas, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | CLINICAL NUCLEAR MEDICINE; v. 35, n. 4, p. 223-227, APR 2010. |
| Web of Science Citations: | 6 |
| Abstract | |
Purpose of the Report: To compare thyroid imaging using Tc-99m sestamibi with the standard Tc-99m pertechnetate scintigraphy in patients on chronic use of amiodarone. Materials and Methods: A total of 23 patients on oral amiodarone for at least 4 months had thyroid scintigraphy and uptake measurement using Tc-99m pertechnetate and Tc-99m sestamibi. Thyroid function was evaluated by measuring serum concentrations of thyrotropin, free thyroxine, and free triiodothyronine, and antithyroglobulin and antithyroperoxidase antibodies. Results: Ten of the 23 patients were euthyroid, 9 hypothyroid, and 4 hyperthyroid, with normal, increased, and decreased serum thyrotropin, respectively. All euthyroid patients had markedly decreased thyroid Tc-99m pertechnetate uptake and normal or slightly increased Tc-99m sestamibi uptake, except for one patient who had increased uptake of both radiotracers. One of the 4 hyperthyroid patients had Graves' disease and markedly increased thyroid uptake of both tracers. The other 3 hyperthyroid patients had normal or decreased Tc-99m pertechnetate uptake and increased Tc-99m sestamibi uptake. Differently than expected, all 9 hypothyroid patients had normal or increased uptake of both radiopharmaceuticals. Conclusions: This study suggests that Tc-99m sestamibi may be an alternative tracer for thyroid scintigraphy and uptake measurement of patients on chronic use of amiodarone. Tc-99m sestamibi seems to be better than Tc-99m pertechnetate for the scintigraphic evaluation of the thyroid of euthyroid and hyperthyroid patients. (AU) | |