Physicochemical stability of poly(lactide-co-glycolide) nanocapsules containing the local anesthetic Bupivacaine

Author(s)

Moraes, Carolina M. ^[1] ; De Paula, Eneida ^[1] ; Rosa, Andre H. ^[2] ; Fraceto, Leonardo F. ^{[1, 2]}

Affiliation

^[1] Univ Estadual Campinas, Inst Biol, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Paulista, Dept Engn Ambiental, BR-18087180 Sorocaba, SP - Brazil

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 21, n. 6, p. 995-1000, 2010.
• Web of Science Citations: 13

Abstract

This paper describes the preparation of poly(DL-lactide-co-glicolide) (PLGA) nanocapsules as a drug carrier system for the local anesthetic bupivacaine. The system was characterized and its stability investigated. The results showed a size distribution with a polydispersity index of 0.12, an average diameter of 148 nm, a zeta potential of -43.5 mV and an entrapment efficiency of 75.8%. The physicochemical properties of polymeric nanocapsule suspensions (average diameter, polydispersity, zeta potential and drug association efficiency) were evaluated as a function of time to determine the formulation stability. The formulation did not display major changes in these properties over the time, and it was considered stable up to 120 days of storage at room temperature. The results reported here which refer to the initial characterization of these new formulations for the local anesthetic bupivacaine show a promising potential for future in vivo studies. (AU)

• FAPESP's process: 06/00121-9 - New formulations for the controlled release of local anesthetics in dentistry: from development to clinical tests
• Grantee: Eneida de Paula
• Support Opportunities: Research Projects - Thematic Grants