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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Heme-oxygenase-2 immunolabelling in pig jejunum

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Author(s):
Matsuda, Nilce Mitiko [1] ; Miller, Steven M. [2] ; Szurszewski, Joseph H. [2]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Cirurgia & Anat, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN - USA
Total Affiliations: 2
Document type: Journal article
Source: ACTA HISTOCHEMICA; v. 112, n. 4, p. 402-406, 2010.
Web of Science Citations: 1
Abstract

Heme-oxygenase-2 generates carbon monoxide in the enteric nervous system and in interstitial cells of Cajal in the canine, mouse and human jejunum. Carbon monoxide is considered a non-adrenergic and non-cholinergic inhibitory neurotransmitter and it establishes and maintains the resting membrane potential in the stomach and small intestine. The aim of this study was to determine the distribution of heme-oxygenase-2 in the enteric nervous system of the pig jejunum. Heme-oxygenase-2 immunoreactivity was found in neurons of myenteric ganglia and in nerve fibers in the circular and longitudinal muscle layers. These results suggest that carbon monoxide is produced in the enteric nervous system of the pig jejunum and might mediate inhibitory neural activity in myenteric ganglia and inhibitory neural input to smooth muscle cells in the circular and longitudinal muscle layers. (C) 2009 Elsevier GmbH. All rights reserved. (AU)