| Full text | |
| Author(s): |
Pomini, Armando M.
[1]
;
Cruz, Pedro L. R.
[1]
;
Gai, Claudia
[2]
;
Araujo, Welington L.
[2]
;
Marsaioli, Anita J.
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Estadual Campinas, Inst Chem, BR-13083970 Campinas, SP - Brazil
[2] Univ Sao Paulo, ESALQ, Dept Genet, BR-13400970 Piracicaba, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Journal of Natural Products; v. 72, n. 12, p. 2125-2129, DEC 2009. |
| Web of Science Citations: | 23 |
| Abstract | |
The acyl-homoserine lactones (acyl-HSLs) produced by Methylobacterium mesophilicum isolated from orange trees infected with the citrus variegated chlorosis (CVC) disease have been studied, revealing the occurrence of six long-chain acyl-HSLs, i.e., the saturated homologues (S)-N-dodecanoyl (1) and (S)-N-tetradecanoyl-HSL (5), the uncommon odd-chain N-tridecanoyl-HSL (3), the new natural product (S)-N-(2E)-dodecenoyl-HSL (2), and the rare unsaturated homologues (S)-N-(7Z)-tetradecenoyl (4) and (S)-N-(2E,7Z)-tetradecadienyl-HSL (6). The absolute configurations of all HSLs were determined as 3S. Compounds 2 and 6 were synthesized for the first time. Antimicrobial assays with synthetic acyl-HSLs against Gram-positive bacterial endophytes co-isolated with M. mesophilicum from CVC-infected trees revealed low or no antibacterial activity. (AU) | |
| FAPESP's process: | 05/02934-4 - Chemical study of signaling substances produced by higher bacteria and eukaryotes |
| Grantee: | Armando Mateus Pomini |
| Support Opportunities: | Scholarships in Brazil - Doctorate |