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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae)

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Author(s):
Oliveira, Camila M. [1] ; Silva, Geraldo H. [2] ; Regasini, Luis O. [1] ; Zanardi, Lisineia M. [1] ; Evangelista, Alana H. [1] ; Young, Maria C. M. [3] ; Bolzani, Vanderlan S. [1] ; Araujo, Angela R. [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Paulista, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, Dept Quim Organ, Inst Quim, BR-14800900 Sao Paulo - Brazil
[2] Univ Fed Sergipe, BR-49500000 Itabaiana, Sergipe - Brazil
[3] Inst Bot, Secao Fisiol & Bioquim Plantas, BR-04301902 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES; v. 64, n. 11-12, p. 824-830, NOV-DEC 2009.
Web of Science Citations: 21
Abstract

In the course of our continuous search for bioactive metabolites from endophytic fungi living in plants from the Brazilian flora, leaves of Alibertia macrophylla (Rubiaceae) were submitted to isolation of endophytes, and two species of Penicillium were isolated. The acetonitrile fraction obtained in corn from a culture of Penicillium sp.1 afforded orcinol (1). On the other hand, Penicillium sp.1 cultivated in potato-dextrose-broth furnished two different compounds, cyclo-(L-Pro-L-Val) (2) and uracil (3). The chromatographic fractionation of the acetonitrile fraction obtained from Penicillium sp.2 led to three dihydroisocoumarins, 4-hydroxymellein (4), 8-methoxymellein (5) and 5-hydroxymellein (6). Compounds 5 and 6 were obtained from the Penicillium genus for the first time. Additionally, metabolites 1-6 were evaluated for their antifungal and acetylcholinesterase (AChE) inhibitory activities. The most active compounds 1. and 4 exhibited detection limits of 5.00 and 10.0 mu g against Cladosporium. cladosporioides and C. sphaerospermum, respectively. Compound 2 showed a detection limit of 10.0 mu g, displaying potent AChE inhibitory activity. (AU)

FAPESP's process: 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II
Grantee:Vanderlan da Silva Bolzani
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants