| Full text | |
| Author(s): |
Porto, Thiago Souza
[1]
;
Furtado, Niege A. J. C.
[2]
;
Heleno, Vladimir C. G.
[1]
;
Martins, Carlos H. G.
[1]
;
Da Costa, Fernando B.
[2]
;
Severiano, Marcela E.
[1]
;
Silva, Aline N.
[1]
;
Veneziani, Rodrigo C. S.
[1]
;
Ambrosio, Sergio R.
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Franca, SP - Brazil
[2] Univ Sao Paulo, Dept Ciencias Farmaceut, Fac Ciencias Farmaceut Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Fitoterapia; v. 80, n. 7, p. 432-436, OCT 2009. |
| Web of Science Citations: | 41 |
| Abstract | |
The dichloromethane crude extract from the roots of Viguiera arenaria (VaDRE) has been employed in an antimicrobial screening against several bacteria responsible for human pathologies. The main diterpenes isolated from this extract, as well as two semi-synthetic pimarane derivatives, were also investigated for the pathogens that were significantly inhibited by the extract (MIC values lower than 100 mu g mL(-1)). The VaDRE extract was significantly active only against Gram-positive microorganisms. The compounds ent-pimara-8(14),15-dien-19-oic acid (PA): PA sodium salt; ent-8(14),15-pimaradien-3 beta-ol; ent-15-pimarene-8 beta,19-diol; and ent-8(14),15-pimaradien-3 beta-acetoxy displayed the highest antibacterial activities (MIC values lower than 10 mu g mL(-1) for most pathogens). In conclusion, our results suggest that pimaranes are an important class of natural products for further investigations in the search of new antibacterial agents. (c) 2009 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 07/54762-8 - Obtaining structural analogues of pimaradienoic acid through the process of fungal biotransformation and study of the effect of these metabolites on the activity of the TcDHODH enzyme and on the contraction of the vascular smooth muscle of the aorta artery of mice |
| Grantee: | Sergio Ricardo Ambrosio |
| Support Opportunities: | BIOTA-FAPESP Program - Young Investigators Grants |