Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo

Author(s):Show less -

Lopes, Stefanie C. P. ^[1] ; Blanco, Yara C. ^[1] ; Justo, Giselle Z. ^[2] ; Nogueira, Paulo A. ^[3] ; Rodrigues, Francisco L. S. ^[3] ; Goelnitz, Uta ^[4] ; Wunderlich, Gerhard ^[4] ; Facchini, Gustavo ^[5] ; Brocchi, Marcelo ^[1] ; Duran, Nelson ^[6] ; Costa, Fabio T. M. ^{[1, 7]}

Affiliation

^[1] Univ Estadual Campinas, UNICAMP, Dept Microbiol & Imunol, Inst Biol, BR-13083970 Campinas, SP - Brazil

^[2] Univ Fed Sao Paulo, UNIFESP, Dept Bioquim, BR-04044020 Sao Paulo - Brazil

^[3] CEPEM, IPEPATRO, BR-78900970 Porto Velho, RO - Brazil

^[4] Univ Sao Paulo, Dept Parasitol, ICB2, Sao Paulo - Brazil

^[5] Univ Estadual Campinas, Dept Fisiol & Biofis, Inst Biol, BR-13083970 Campinas, SP - Brazil

^[6] Univ Estadual Campinas, Lab Quim Biol, Inst Quim, BR-13083970 Campinas, SP - Brazil

^[7] Univ Estadual Campinas, UNICAMP, Dept Parasitol, Inst Biol, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: Antimicrobial Agents and Chemotherapy; v. 53, n. 5, p. 2149-2152, MAY 1 2009.
• Web of Science Citations: 50

Abstract

Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge. (AU)

• FAPESP's process: 04/00638-6 - Analysis of the immune response against surface antigens of human erythrocytes infected by Plasmodium spp.: emphasis on the improvement of vaccines and development of monoclonal antibodies
• Grantee: Fabio Trindade Maranhão Costa
• Support Opportunities: Research Grants - Young Investigators Grants