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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

HPV variants and HLA polymorphisms: the role of variability on the risk of cervical cancer

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de Araujo Souza, Patricia Savio [1] ; Sichero, Laura [2] ; Maciag, Paulo Cesar [3]
Total Authors: 3
[1] Brazilian Natl Canc Inst, Div Cellular Biol, BR-22231090 Rio De Janeiro - Brazil
[2] Hosp Alemao Oswaldo Cruz, Ludwig Inst Canc Res, BR-01323903 Sao Paulo - Brazil
[3] Advaxis Inc, N Brunswick, NJ 08902 - USA
Total Affiliations: 3
Document type: Review article
Source: FUTURE ONCOLOGY; v. 5, n. 3, p. 359-370, APR 2009.
Web of Science Citations: 33

Human papillomavirus (HPV) infection is linked to the development of cervical cancer, and several cofactors contribute to the risk of disease. Research on the intratypic variability of HPVs has defined variants that are associated with persistent infections and are potentially more oncogenic, translating to a higher risk of malignant disease. The genetic variability of the host also plays a role in the risk of cervical cancer, especially genes controlling the immune response, such as HLA class I and II. These highly polymorphic genes are important risk determinants of HPV persistence and disease progression. The interaction between host and viral factors is complex and needs to be further investigated, paving the way to better define the patients at the highest risk of developing malignant diseases linked to HPV infection, (AU)