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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hospital strain colonization by Staphylococcus epidermidis

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Author(s):
Blum-Menezes, D. [1, 2] ; Bratfich, O. J. [1] ; Padoveze, M. C. [1] ; Moretti, M. L. [1]
Total Authors: 4
Affiliation:
[1] Univ Estadual Campinas, Fac Ciencias Med, Lab Epidemiol Mol Bacterias & Fungos, Disciplina Infectol, Campinas, SP - Brazil
[2] Univ Fed Pelotas, Inst Biol, Dept Microbiol & Parasitol, Pelotas, RS - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 42, n. 3, p. 294-298, MAR 2009.
Web of Science Citations: 3
Abstract

The skin and mucous membranes of healthy subjects are colonized by strains of Staphylococcus epidermidis showing a high diversity of genomic DNA polymorphisms. Prolonged hospitalization and the use of invasive procedures promote changes in the microbiota with subsequent colonization by hospital strains. We report here a patient with prolonged hospitalization due to chronic pancreatitis who was treated with multiple antibiotics, invasive procedures and abdominal surgery. We studied the dynamics of skin colonization by S. epidermidis leading to the development of catheter-related infections and compared the genotypic profile of clinical and microbiota strains by pulsed field gel electrophoresis. During hospitalization, the normal S. epidermidis skin microbiota exhibiting a polymorphic genomic DNA profile was replaced with a hospital-acquired biofilm-producer S. epidermidis strain that subsequently caused repetitive catheter-related infections. (AU)