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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The maspin expression in canine mammary tumors: An immunohistochemical and molecular study

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Zuccari, Debora A. P. C. [1] ; Castro, Rodrigo [2] ; Gavioli, Arieli F. [3] ; Mancini, Ulises M. [4] ; Tajara, Eloisa H. [4] ; Frade, Cibelli S. [2] ; Pivaro, Luana R. [2] ; Carmona-Raphe, Juliana [4] ; Terzian, Ana Carolina B. [5] ; Ruiz, Camila M. [6] ; Goloni Bertollo, Eny M. [2] ; Pavarino-Bertelli, Erika C. [2]
Total Authors: 12
[1] Fac Med Sao Jose Rio Preto, Ctr Reg Bioterismo, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[2] FAMERP, Unidade Pesquisa Genet & Biol Mol, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Estadual Paulista, Lab Patol Anim, BR-16050680 Aracatuba, SP - Brazil
[4] FAMERP, Lab Bioinformat, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[5] FAMERP, Lab Pesquisa Virol, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[6] Lab Patol & Biol Mol Vet, BR-13073022 Campinas, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 29, n. 2, p. 167-173, FEB 2009.
Web of Science Citations: 1

The serpin maspin, a tumor suppressor in breast cancer was described as an inhibitor of cell migration and inducer of cell adhesion between the basement membrane and extracellular matrix resulting in inhibition of tumor metastasis. In contrast, overexpression of maspin is correlated with poor prognosis in other types of cancer. Little is known about expression, regulation and function of maspin in canine mammary tumors. It was demonstrated in this study, a loss of maspin expression in malignant canine mammary cells compared with a pool of normal canine mammary tissue, analyzed by quantitative real-time PCR; weak maspin expression in malignant canine mammary tumors were observed by immunohistochemistry. It was also demonstrated that a correlation with nuclear maspin expression and a good prognosis. It is suggested that maspin could be used as a prognostic marker in canine mammary neoplasia. (AU)