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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer

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Author(s):
Badiglian Filho, Levon [1] ; Fujiyama Oshima, Celina Tizuko [2] ; Lima, Flavio De Oliveira [2] ; Costa, Henrique De Oliveira [2] ; Damiao, Roberio De Sousa [1] ; Gomes, Thiago Simao [2] ; Goncalves, Wagner Jose [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo, Dept Gynecol, Discipline Gynecol Oncol, BR-01424000 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Pathol, BR-01424000 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ONCOLOGY REPORTS; v. 21, n. 2, p. 313-320, FEB 2009.
Web of Science Citations: 50
Abstract

The Wnt family is involved in tumorigenesis of several tissues. In ovarian cancer, the role played by Writs and its pathways is not clearly defined. In order to analyze the canonical and noncanonical Writ pathway in normal ovary, benign ovarian tumor and ovarian cancer, we evaluated the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and B-catenin. Ovarian specimens were obtained from surgeries performed between 1993 and 2004. The patients were divided in three groups: group A, epithelial ovarian cancer (n=38); group B, benign epithelial neoplasia (n=28); and group C, normal ovaries (n=26). Immunoreactivity for Wnt1, FZD1, Wnt5a, FZD5 and B-catenin was scored for each group. The proportion of Wnt1 positive women in group A (29.4%) was significantly higher than in group B (4.3%) and C (9.1%) (p=0.020). The proportion of FZD1 positive patients in group C (54.5%) was significantly lower than in group A (97.1%) and B (90.0%) (p<0.001). The proportion of Wnt5a positive women was significantly higher for group A (80.0%) compared to group B (25.0%) and C (27.3%) (p<0.001). The proportion of beta-catenin positive patients in group C (95.8%) was significantly higher than group B (52.4%) (p=0.004). Comparison of the survival curves in group A according to Wnt5a expression showed a significant difference between positive and negative patients, whereas the Wnt5a positive women showed worse results (p=0.050). Our findings suggest that the pathways related to Wnt5a have an important role in ovarian malignant neoplasia. Furthermore, Wnt5a was found to be a predictor of poor prognosis for ovarian cancer. (AU)