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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Analysis of Craniofacial and Extremity Growth in Patients with Growth Hormone Deficiency during Growth Hormone Therapy

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Author(s):
Justamante de Faria, Maria Estela [1] ; Carvalho, Luciani R. [2] ; Rossetto, Shirley M. [3] ; Amaral, Terezinha Sampaio [4] ; Berger, Karina [2] ; Prado Arnhold, Ivo Jorge [2] ; Mendonca, Berenice Bilharinho [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Med, Hosp Clin, Div Odontol, Inst Cent, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin, Unidade Endocrinol Desenvolvimento, Lab Hormonios & Genet Mol LIM 42, Sao Paulo - Brazil
[3] Disciplina Ortodontia Especializacao, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Hosp Clin, Dept Radiol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: HORMONE RESEARCH; v. 71, n. 3, p. 173-177, 2009.
Web of Science Citations: 5
Abstract

Background/Aims: There are many controversies regarding side effects on craniofacial and extremity growth due to growth hormone ( GH) treatment. Our aim was to estimate GH action on craniofacial development and extremity growth in GH-deficient patients. Methods: Twenty patients with GH deficiency with a chronological age ranging from 4.6 to 24.3 years (bone age from 1.5 to 13 years) were divided in 2 groups: group 1 (n = 6), naive to GH treatment, and group 2 (n = 14), ongoing GH treatment for 2-11 years. GH doses (0.1 -0.15 U/kg/day) were adjusted to maintain insulin-like growth factor 1 and insulin-like growth factor binding protein 3 levels within the normal range. Anthropometric measurements, cephalometric analyses and facial photographs to verify profile and harmony were performed annually for at least 3 years. Results: Two patients with a disharmonious profile due to mandibular growth attained harmony, and none of them developed facial disharmony. Increased hand or foot size (>P97) was observed in 2 female patients and in 4 patients (1 female), respectively, both not correlated with GH treatment duration and increased levels of insulin-like growth factor 1. Conclusions: GH treatment with standard doses in GH-deficient patients can improve the facial profile in retrognathic patients and does not lead to facial disharmony although extremity growth, mainly involving the feet, can occur. Copyright (C) 2009 S. Karger AG, Basel (AU)