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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The presence of CD56/CD16 in T-cell acute lymphoblastic leukaemia correlates with the expression of cytotoxic molecules and is associated with worse response to treatment

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Author(s):
Dalmazzo, Leandro F. F. [1] ; Jacomo, Rafael H. [1] ; Marinato, Andre F. [1] ; Figueiredo-Pontes, Lorena L. [1] ; Cunha, Renato L. G. [1] ; Garcia, Aglair B. [1] ; Rego, Eduardo M. [1] ; Falcao, Roberto P. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Med Sch Ribeirao Preto, Ctr Cell Based Therapy, BR-14048900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: British Journal of Haematology; v. 144, n. 2, p. 223-229, JAN 2009.
Web of Science Citations: 18
Abstract

Some cases of T-cell acute lymphoblastic leukaemia (ALL) express markers found in natural-killer (NK) cells, such as CD56 and CD16. Out of 84 T-cell ALL cases diagnosed at our Institution, CD56 and/or CD16 was detected in 24 (28.5%), which we designated T/NK-ALL group. Clinical features, laboratory characteristics, survival and expression of cytotoxic molecules were compared in T/NK-ALL and T-ALL patients. Significant differences were observed regarding age (24.9 vs. 16.4 years in T/NK-ALL and T-ALL, respectively, P = 0.006) and platelet counts (177 x 10(9)/l vs. 75 x 10(9)/l in T/NK-ALL and T-ALL, respectively, P = 0.03). Immunophenotypic analysis demonstrated that CD34, CD45RA and CD33 were more expressed in T/NK-ALL patients, whereas CD8 and terminal deoxynucleotidyl transferase were more expressed in T-ALL patients (P < 0.05). The mean overall survival (863 vs. 1869 d, P = 0.02) and disease-free survival (855 vs. 2095 d, P = 0.002) were shorter in patients expressing CD56/CD16. However, multivariate analysis identified CD56/CD16 as an independent prognostic factor only for DFS. Cytotoxic molecules were highly expressed in T/NK-ALL compared to T-ALL. Perforin, granzyme B and TIA-1 were detected in 12/17, 4/17 and 7/24 T/NK-ALL patients and in 1/20, 0/20 and 1/20 T-ALL respectively (P < 0.001, P = 0.036 and P = 0.054). Therefore, the presence of CD56/CD16 was associated with distinct clinical features and expression of cytotoxic molecules in the blasts. (AU)

FAPESP's process: 05/04296-5 - Annexin II expression quantitative evaluation and its correlation with laboratorial fibrinolysis parameters in Acute Promyelocytic Leukemia in humans and in transgenic model (hCG-PML-RARa)
Grantee:Rafael Henriques Jácomo
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)