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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Efficiency of intermittent exercise on adiposity and fatty liver in rats fed with high-fat diet

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Author(s):
Sene-Fiorese, Marcela [1, 2] ; Duarte, Fernanda O. [1] ; Scarmagnani, Flavia R. R. [1] ; Cheik, Nadia C. [1] ; Manzoni, Marla S. J. [1] ; Nonaka, Keico O. [3] ; Rossi, Eliseu A. [4] ; de Oliveira Duarte, Ana C. G. [1] ; Damaso, Ana R. [4]
Total Authors: 9
Affiliation:
[1] Univ Fed Sao Carlos, Ctr Biol & Hlth Sci, Dept Educ Phys, Lab Nutr & Metab Appl Exercise, Sao Paulo - Brazil
[2] Univ Camilo Castelo Branco, Fac Phys Educ, Sao Paulo - Brazil
[3] Univ Fed Sao Carlos, Ctr Biol & Hlth Sci, Dept Physiol Sci, Sao Paulo - Brazil
[4] Univ Estadual Paulista, Fac Pharmaceut Sci, Dept Food & Nutr, Araraquara - Brazil
Total Affiliations: 4
Document type: Journal article
Source: OBESITY; v. 16, n. 10, p. 2217-2222, OCT 2008.
Web of Science Citations: 28
Abstract

Objective: This study aimed to examine and compare the effects of continuous or intermittent exercises on adiposity and fatty liver in rats fed with high-fat diet. Methods and Procedures: Wistar rats were divided according to diet composition-chow diet (C) or high-fat diet (H)-and kinds of exercise-sedentary (S), continuous (CE), or intermittent (IE) exercises. The CE group swam 90 min/day, and the IE group swam 3 x 30 min/day (at 4-h intervals between sessions); both groups exercised 5 days/week during 8 weeks. Body weight and food intake were recorded daily. Lipogenesis rate in vivo was determined by the incorporation of (H2O)-H-3 into saponified lipids in retroperitoneal (RET), epididymal (EPI), and visceral (VIS) white adipose tissues, brown adipose tissue (BAT), liver (L), and gastrocnemius muscle (GAST) using the gravimetric method. Total cholesterol, high-density lipoprotein (HDL)-cholesterol, and triacylglycerol (TG) were analyzed. Results: The major finding of this study is that IE was more efficient than CE in reducing the adverse effects of high-fat diet and sedentarism. There was an improvement in the lipid profile and a reduction in food intake, body weight gain, visceral and central adiposity, and fatty liver, contributing to the control of obesity and other comorbidities, including nonalcoholic fat liver diseases. Discussion: Earlier studies have discussed the effects of diet consumption on adiposity and their relation to chronic diseases and obesity. This study discusses the effects of high-fat diet consumption and the different kinds of exercise on weight gain, adiposity, fatty liver, and lipid profile in rats. The results may depend on the exercise, time of each session, age, gender, and experimental period. (AU)