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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion

Full text
Author(s):
Latini, Flavia R. M. [1] ; Hemerly, Jefferson P. [1] ; Oler, Gisele [1] ; Riggins, Gregory J. [2] ; Cerutti, Janete M. [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Paulo, Dept Morphol & Genet, Div Genet, Genet Bases Thyroid Tumors Lab, BR-04039032 Sao Paulo - Brazil
[2] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21205 - USA
Total Affiliations: 2
Document type: Journal article
Source: Endocrine-Related Cancer; v. 15, n. 3, p. 787-799, SEP 2008.
Web of Science Citations: 34
Abstract

Loss of ABI gene family member 3-binding protein (ABI3BP) expression may be functionally involved in the pathogenesis of cancer. Previous reports have indicated a loss of expression in lung cancer and a presumed role in inducing cellular senescence. We show here that ABI3BP expression is significantly decreased in most malignant thyroid tumors of all types. To better understand ABI3BPs role, we created a model by re-expressing ABI3BP in two thyroid cancer cell lines. Re-expression of ABI3BP in thyroid cells resulted in a decrease in transforming activity, cell growth, cell viability, migration, invasion, and tumor growth in nude mice. ABI3BP re-expression appears to trigger cellular senescence through the p21 pathway. Additionally, ABI3BP induced formation of heterochromatin 1-binding protein gamma-positive senescence-associated (SA) heterochromatin foci and accumulation of SA beta-galactosidase. The combination of a decrease in cell growth, invasion, and other effects upon ABI3BP re-expression in vitro helps to explain the large reduction in tumor growth that we observed in nude mice. Together, our data provide evidence that the loss of ABI3BP expression could play a functional role in thyroid tumorigenesis. Activation of ABI3BP or its pathway may represent a possible basis for targeted therapy of certain cancers. Endocrine-Related Cancer (2008) 15 787-799 (AU)

FAPESP's process: 05/60330-8 - Molecular markers in diagnosis and prognosis of patients with tumors of the human thyroid: transition from basic to clinical research
Grantee:Janete Maria Cerutti
Support Opportunities: Research Projects - Thematic Grants