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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Modeling, Simulation, and Experimental Evaluation of Continuous Chromatographic Separation of Ketamine Enantiomers on MCTA

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Author(s):
Barreto, Jr., Amaro Gomes [1] ; da Silva, Jr., Ivanildo Jose [2] ; Garcia dos Santos, Marco Antonio [3] ; de Veredas, Vinicius [3] ; Santana, Cesar Costapinto [3]
Total Authors: 5
Affiliation:
[1] Univ Fed Rio de Janeiro, Escola Quim, Edificio Ctr Technol, Dept Engn Quim, Rio De Janeiro - Brazil
[2] Univ Fed Cerara, Ctr Technol, Dept Engn Quim, GPSA, Fortaleza, Ceara - Brazil
[3] Univ Estadual Campinas, Fac Engn Quim, Dept Proc Biotecnol, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Liquid Chromatography & Related Technologies; v. 31, n. 20, p. 3057-3076, 2008.
Web of Science Citations: 4
Abstract

Results on the chiral separation of ketamine enantiomers by simulated moving bed (SMB) chromatography using microcrystalline cellulose triacetate (MCTA) columns are reported. Experimental data obtained with the SMB laboratory unit showed purities above 99.5% in the raffinate stream and above 97.7% in the extract stream. A simulation approach based on true moving bed (TMB) was applied to validate the performance of the SMB in steady state regime, taking into account the non-linear isotherms, non-ideal effects, and the non-homogeneities of the eight columns. The experimental and calculated results are in agreement with the internal profiles calculated by the TMB approach. (AU)

FAPESP's process: 06/02511-9 - Design of experiments and optimization of operating conditions in a simulated moving bed: application in chiral drugs separation
Grantee:Amaro Gomes Barreto Júnior
Support Opportunities: Scholarships in Brazil - Post-Doctoral