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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Diabetic Peripheral Neuropathies: A Morphometric Overview

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Author(s):
Sassoli Fazan, Valeria Paula [1, 2] ; Carvalho de Vasconcelos, Carlos Augusto [3, 4] ; Valenca, Marcelo Moraes [4] ; Nessler, Randy [1] ; Moore, Kenneth Charles [1]
Total Authors: 5
Affiliation:
[1] Univ Iowa, Cent Microscopy Res Facil, Iowa City, IA 52241 - USA
[2] USP, Sch Med Ribeirao Preto, Dept Surg & Anat, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Fed Pernambuco, Elect Microscopy Sect, LIKA, Recife, PE - Brazil
[4] Univ Fed Pernambuco, Div Neurol & Neurosurg, Dept Neuropsychiat, BR-50670901 Recife, PE - Brazil
Total Affiliations: 4
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF MORPHOLOGY; v. 28, n. 1, p. 51-64, MAR 2010.
Web of Science Citations: 7
Abstract

Diabetes is now considered one of the main threats to human health in the 21st century and many researchers are dedicated to investigate the physiopathology of the disease, with further insights on the managements of its major complications. Since understanding the pathophysiology of the major complications of diabetes and their underlying processes is mandatory, experimental models of the disease may be useful as they allow the recognition of the early mechanisms involved in the long-term complications of diabetes. Peripheral nerve involvement is highly frequent in diabetes mellitus and it has been documented that one third of diabetic patients have peripheral neuropathy. The true prevalence is not known and reports vary from 10% to 90% in diabetic patients, depending on the criteria and methods used to define neuropathy. In this review, the most common experimental models of diabetes are presented and the pathological findings on major peripheral nerves are discussed. Also, the insights brought by morphometry to the diabetic neuropathy research are highlighted. (AU)

FAPESP's process: 06/06362-8 - Ultrastructural morphological evaluation of renal nerve alterations in experimentally induced diabetic rats
Grantee:Valéria Paula Sassoli Fazan
Support Opportunities: Scholarships abroad - Research