| Full text | |
| Author(s): Show less - |
Tofoli, Giovana Radomille
[1, 2]
;
Saia Cereda, Cintia Maria
[1]
;
de Araujo, Daniele Ribeiro
[3, 1]
;
de Paula, Eneida
[1]
;
Brito Junior, Rui Barbosa
[4]
;
Pedrazzoli Junior, Jose
[2]
;
Meurer, Eduardo
[2]
;
Proenca Barros, Fabio Alessandro
;
Groppo, Francisco Carlos
[5]
;
Volpato, Maria Cristina
[5]
;
Ranali, Jose
[5]
Total Authors: 11
|
| Affiliation: | [1] Univ Estadual Campinas, Dept Biochem, Inst Biol, BR-13083970 Campinas, SP - Brazil
[2] Univ Sao Francisco, UNIFAG Clin Pharmacol & Gastroenterol Unit, BR-12900000 Braganca Paulista, SP - Brazil
[3] Fed Univ ABC, Human & Nat Sci Ctr, Santo Andre, SP - Brazil
[4] Sao Leopoldo Mand Dent Res Inst, Dept Mol Biol, Campinas, SP - Brazil
[5] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, Piracicaba, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | DRUG DELIVERY; v. 17, n. 2, p. 68-76, FEB 2010. |
| Web of Science Citations: | 6 |
| Abstract | |
The pharmacokinetics and the local toxicity of commercial and liposome-encapsulated mepivacaine formulations injected intra-orally in rats were studied. Animals were divided in groups (n=4-6) and treated with 0.1 mL of the formulations: 2% mepivacaine with 1:100,000 epinephrine (MVC(2%EPI)), 3% mepivacaine (MVC(3%)), and 2% liposome-encapsulated mepivacaine (MVC(LUV)). The results showed that the 2% liposome-encapsulated mepivacaine reduced C(max), prolonged AUC(0-infinity) and t(1/2) compared with 3% plain and 2% vasoconstritor-associated mepivacaine, after intraoral injection. In addition, it was also observed that liposomal mepivacaine might protect the tissue against local inflammation evoked by plain or vasoconstrictors-associated mepivacaine, giving supporting evidence for its safety and possible clinical use in dentistry. (AU) | |
| FAPESP's process: | 06/00121-9 - New formulations for the controlled release of local anesthetics in dentistry: from development to clinical tests |
| Grantee: | Eneida de Paula |
| Support Opportunities: | Research Projects - Thematic Grants |