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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Micronutrient prenatal supplementation prevents the development of hypertension and vascular endothelial damage induced by intrauterine malnutrition

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Author(s):
Franco, Maria do Carmo [1] ; Ponzio, Beatriz Felice [2] ; Gomes, Guiomar Nascimento [3] ; Gil, Frida Zaladek [3] ; Tostes, Rita [2, 4] ; Catelli Carvalho, Maria Helena [2] ; Fortes, Zuleica Bruno [2]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo, Div Nephrol, Dept Med, BR-04023900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Renal Physiol, BR-04023900 Sao Paulo - Brazil
[4] Med Coll Georgia, Dept Physiol, Augusta, GA 30912 - USA
Total Affiliations: 4
Document type: Journal article
Source: Life Sciences; v. 85, n. 7-8, p. 327-333, AUG 12 2009.
Web of Science Citations: 30
Abstract

Aims: The premise that intrauterine malnutrition plays an important role in the development of cardiovascular and renal diseases implies that these disorders can be programmed during fetal life. Here, we analyzed the hypothesis that supplementation with mixed antioxidant vitamins and essential mineral in early life could prevent later elevation of blood pressure and vascular and renal dysfunction associated with intrauterine malnutrition. Main methods: For this, female Wistar rats were randomly divided into three groups on day 1 of pregnancy: control fed standard chow ad libitum; restricted group fed 50% of the ad libitum intake and a restricted plus micronutrient cocktail group treated daily with a combination of micronutrient (selenium, folate, vitamin C and vitamin E) by oral gavage. Key findings: In adult offspring, renal function and glomerular number were impaired by intrauterine malnutrition. and the prenatal micronutrient treatment did not prevent it. However, increased blood pressure and reduced endothelium-dependent vasodilation were prevented by the micronutrient prenatal treatment. Intrauterine malnutrition also led to reduced NO production associated with increased superoxide generation, and these parameters were fully normalized by this prenatal treatment. Significance: Our current findings indicate that programming alterations during fetal life can be prevented by interventions during the prenatal period, and that disturbance in availability of both antioxidant vitamins and mineral may play a crucial role in determining the occurrence of long-term cardiovascular injury. (C) 2009 Elsevier Inc. All rights reserved. (AU)