| Full text | |
| Author(s): Show less - |
Gureje, O.
[1]
;
Oladeji, B.
[1]
;
Hwang, I.
[2]
;
Chiu, W. T.
[2]
;
Kessler, R. C.
[2]
;
Sampson, N. A.
[2]
;
Alonso, J.
[3]
;
Andrade, L. H.
[4, 5]
;
Beautrais, A.
[6]
;
Borges, G.
[7]
;
Bromet, E.
[8]
;
Bruffaerts, R.
[9]
;
de Girolamo, G.
[10]
;
de Graaf, R.
[11]
;
Gal, G.
[12]
;
He, Y.
[13]
;
Hu, C.
[14]
;
Iwata, N.
[15]
;
Karam, E. G.
[16]
;
Kovess-Masfety, V.
[17]
;
Matschinger, H.
[18]
;
Moldovan, M. V.
[19]
;
Posada-Villa, J.
[20]
;
Sagar, R.
[21]
;
Scocco, P.
[22]
;
Seedat, S.
[23]
;
Tomov, T.
[24]
;
Nock, M. K.
[25]
Total Authors: 28
|
| Affiliation: Show less - | [1] Univ Coll Hosp, Dept Psychiat, Ibadan - Nigeria
[2] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 - USA
[3] Hosp del Mar, Inst Municipal Invest Med, Hlth Serv Res Unit, CIBERESP, Barcelona, Catalonia - Spain
[4] Univ Sao Paulo, Sch Med, Inst Psychiat, Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo - Brazil
[6] Univ Otago, Christchurch - New Zealand
[7] Inst Nacl Psiquiatria Ramon de la Fuente, Mexico City, DF - Mexico
[8] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 - USA
[9] Katholieke Univ Leuven, Louvain - Belgium
[10] IRCCS Ctr S Giovanni Dio Fatebenefratelli, Bologna - Italy
[11] Netherlands Inst Mental Hlth & Addict, Utrecht - Netherlands
[12] Chaim Sheba Med Ctr, Gertner Inst Epidemiol & Hlth Policy Res, IL-52621 Tel Hashomer - Israel
[13] Shanghai Mental Hlth Ctr, Shanghai - Peoples R China
[14] Shenzhen Inst Mental Hlth, Shenzhen, Guangdong - Peoples R China
[15] Hiroshima Int Univ, Higashihiroshima - Japan
[16] St George Hosp Univ Med Ctr, IDRAAC, Dept Psychiat & Clin Psychol, Beirut - Lebanon
[17] Univ Paris 05, EA4069, Paris - France
[18] Univ Leipzig, Psychiat Clin, Leipzig - Germany
[19] Natl Sch Publ Hlth & Hlth Serv Management, Bucharest - Romania
[20] Saldarriaga Concha Fdn, Bogota - Colombia
[21] All India Inst Med Sci, New Delhi - India
[22] Dept Mental Hlth, Padua - Italy
[23] MRC Res Unit Anxiety & Stress Disorder, Cape Town - South Africa
[24] New Bulgarian Univ, Sofia - Bulgaria
[25] Harvard Univ, Cambridge, MA 02138 - USA
Total Affiliations: 25
|
| Document type: | Journal article |
| Source: | MOLECULAR PSYCHIATRY; v. 16, n. 12, p. 1221-1233, 2010. |
| Web of Science Citations: | 38 |
| Abstract | |
Previous research suggests that parental psychopathology predicts suicidal behavior among offspring; however, the more fine-grained associations between specific parental disorders and distinct stages of the pathway to suicide are not well understood. We set out to test the hypothesis that parental disorders associated with negative mood would predict offspring suicide ideation, whereas disorders characterized by impulsive aggression (for example, antisocial personality) and anxiety/agitation (for example, panic disorder) would predict which offspring act on their suicide ideation and make a suicide attempt. Data were collected during face-to-face interviews conducted on nationally representative samples (N=55 299; age 18+) from 21 countries around the world. We tested the associations between a range of parental disorders and the onset and persistence over time (that is, time since most recent episode controlling for age of onset and time since onset) of subsequent suicidal behavior (suicide ideation, plans and attempts) among offspring. Analyses tested bivariate and multivariate associations between each parental disorder and distinct forms of suicidal behavior. Results revealed that each parental disorder examined increased the risk of suicide ideation among offspring, parental generalized anxiety and depression emerged as the only predictors of the onset and persistence (respectively) of suicide plans among offspring with ideation, whereas parental antisocial personality and anxiety disorders emerged as the only predictors of the onset and persistence of suicide attempts among ideators. A dose-response relation between parental disorders and respondent risk of suicide ideation and attempt was also found. Parental death by suicide was a particularly strong predictor of persistence of suicide attempts among offspring. These associations remained significant after controlling for comorbidity of parental disorders and for the presence of mental disorders among offspring. These findings should inform future explorations of the mechanisms of intergenerational transmission of suicidal behavior. Molecular Psychiatry (2011) 16, 1221-1233; doi:10.1038/mp.2010.111; published online 16 November 2010 (AU) | |
| FAPESP's process: | 03/00204-3 - Epidemiological study of psychiatric disorders in the São Paulo Metropolitan Region: prevalence, risk factors, and social and economical burden |
| Grantee: | Laura Helena Silveira Guerra de Andrade |
| Support Opportunities: | Research Projects - Thematic Grants |