Trends of oral and oropharyngeal cancer survival over five decades in 3267 patients treated in a single institution

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Author(s):	Carvalho‚ A.L. ; Ikeda‚ M.K. ; Magrin‚ J. ; Kowalski‚ L.P. Total Authors: 4
Document type:	Journal article
Source:	Oral Oncology; v. 40, n. 1, p. 71-76, 2004.
Abstract
The objective of this study was to analyze the influence of changes in the treatment on the prognosis of patients treated over 44 years in a single institution. The 5-decade trends in treatment approach and 5-year survival of 3267 patients treated between 1953 and 1997 were analyzed. An increase was observed in primary surgical treatment and its association with radiotherapy. In the 1950s, 29.1% of the patients were treated by surgery, 54.5% by radiotherapy and 16.4% by combined treatment; in the 1990s, these proportions were 39.7, 9.7 and 50.6%, respectively (P<0.001). There was a significant increase in the 5-year survival rates from 28.7% for patients treated in the 1950s to 43.2% in the 1990s (P<0.001). The changes in treatment approach for oral and oropharyngeal cancer over the last 5 decades, with an increase of surgical treatment and its combination with radiotherapy significantly improved the survival rates. (C) 2003 Elsevier Ltd. All. rights reserved. (AU)

FAPESP's process:	98/14335-2 - Antonio Prudente Cancer Research Center
Grantee:	Fernando Augusto Soares
Support Opportunities:	Research Grants - Research, Innovation and Dissemination Centers - RIDC