Bed nucleus of the stria terminalis and the cardiovascular responses to chemoreflex activation

Author(s)

Granjeiro, Erica M. ^[1] ; Gomes, Felipe V. ^[2] ; Alves, Fernando H. F. ^[2] ; Crestani, Carlos C. ^[3] ; Correa, Fernando M. A. ^[2] ; Resstel, Leonardo B. M. ^[2]

Affiliation

^[1] Univ Sao Paulo, Dept Physiol, Sch Med Ribeirao Preto, BR-14090090 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, BR-14090090 Ribeirao Preto, SP - Brazil

^[3] Sao Paulo State Univ, UNESP, Dept Nat Act Principles & Toxicol, Sch Pharmaceut Sci Araraquara, BR-14801902 Araraquara, SP - Brazil

• Document type: Journal article
• Source: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 167, n. 1-2, p. 21-26, APR 3 2012.
• Web of Science Citations: 5

Abstract

Several studies from our group have indicated that the BNST play an important role in baroreflex modulation. However, the involvement of the BNST in the chemoreflex activity is unknown. Thus, in the present study, we investigated the effect of the local bed nucleus of stria terminalis (BNST) neurotransmission inhibition by bilateral microinjections of the non-selective synaptic blocker cobalt chloride (CoCl2) on the cardiovascular responses to chemoreflex activation in rats. For this purpose, chemoreflex was activated with KCN (i.v.) before and after microinjections of CoCl2 into the BNST. Reversible BNST inactivation produced no significant changes in the magnitude and durations of both pressor and bradycardic responses to intravenous KCN infusion. These findings suggesting that BNST neurotransmission have not influence on both sympathoexcitatory and parasympathoexcitatory components of the peripheral chemoreflex activation. (C) 2012 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 10/17343-0 - Evaluation of CBD effects on the molecular and behavioral changes induced by repeated treatment with MK-801
• Grantee: Felipe Villela Gomes
• Support Opportunities: Scholarships in Brazil - Doctorate