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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Plasma cortisol in first episode drug-naive mania: Differential levels in euphoric versus irritable mood

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Author(s):
Valiengo, Leandro L. [1] ; Soeiro-de-Souza, Marcio G. [2] ; Marques, Andrea H. [3] ; Moreno, Doris H. [2] ; Juruena, Mario F. [4] ; Andreazza, Ana Cristina [5, 6] ; Gattaz, Wagner F. [1] ; Machado-Vieira, Rodrigo [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Lab Neurosci, Inst & Dept Psychiat, BR-01060970 Sao Paulo - Brazil
[2] Univ Sao Paulo HC FMUSP, Mood Disorders Unit GRUDA, Dept & Inst Psychiat, Sch Med, Sao Paulo - Brazil
[3] NIMH, Genet Epidemiol Branch, NIH, Bethesda, MD 20892 - USA
[4] Univ Sao Paulo, Dept Neurosci & Behav Sci, Ribeirao Preto, SP - Brazil
[5] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY - USA
[6] Univ Toronto, Dept Psychiat, Toronto, ON - Canada
Total Affiliations: 6
Document type: Journal article
Source: Journal of Affective Disorders; v. 138, n. 1-2, p. 149-152, APR 2012.
Web of Science Citations: 16
Abstract

Background: Dysregulation of HPA axis has been widely described in subjects with bipolar disorder (BD), including changes in cortisol levels during mood episodes and euthymia. However, most of the studies were done with medicated BD patients with variable length of illness, which was shown to interfere on peripheral cortisol levels. Therefore, the present study aims to evaluate plasma cortisol levels in drug-naive BD subjects during the first manic episode, as well as investigate the relationship between plasma cortisol levels and manic symptomatology. Methods: Twenty-six drug-naive patients were enrolled meeting criteria for a first manic episode in bipolar I disorder. Severity of mania was assessed using the Young Mania Rating Scale (YMRS). The control group included 27 healthy subjects matched by age and gender. Cortisol was quantified using a direct radioimmunoassay. Results: Plasma cortisol levels were decreased during first manic episode compared to healthy controls. Higher cortisol levels were positively associated with the presence of irritability (dysphoria), while elated mania showed lower cortisol levels compared to controls. Limitation: Data including larger samples are lacking. Conclusion: Higher cortisol in dysphoric mania compared to predominantly elated/euphoric mania may indicate a clinical and neurobiological polymorphic phenomenon, potentially involving a higher biological sensitivity to stress in the presence of irritable mood. The present findings highlight the importance to add a dimensional approach to the traditional categorical diagnosis for future neurobiological studies in BD. (C) 2011 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 09/14891-9 - Longitudinal study on the neuroprotective and neurotrophic effects of lithium in bipolar disorder: identification of cellular and molecular targets clinically relevant
Grantee:Rodrigo Machado-Vieira
Support Opportunities: Research Grants - Young Investigators Grants