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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of microinjections of apomorphine and haloperidol into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in rat

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Author(s):
Satake, Susan [1] ; Yamada, Karen [1] ; Melo, Liana Lins [1] ; Silva, Regina Barbosa [1]
Total Authors: 4
Affiliation:
[1] Univ Fed Sao Paulo Unifesp, Dept Biociencias, Lab Psicol Expt, BR-11060001 Santos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Neuroscience Letters; v. 509, n. 1, p. 60-63, FEB 10 2012.
Web of Science Citations: 13
Abstract

Prepulse inhibition (PPI) is the reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus and is an operational measure of sensorimotor gating. PPI is impaired in schizophrenia patients and in rats with central dopamine (DA) activation. The inferior colliculus (IC) is a critical part of the auditory pathway mediating acoustic PPI. The activation of the IC by the acoustic prepulse reduces startle magnitude. The aim of this study was to elucidate the role of DA transmission of the IC on the development of acoustic PPI. Bilateral microinjections of apomorphine (9.0 mu g/0.5 mu L) an agonist of D-2 receptors, into the IC disrupted PPI while microinjections of haloperidol (0.5 mu g/0.5 mu L), an antagonist of D-2 receptors, into this structure did not alter PPI. These results suggest that dopamine-mediated mechanisms of the IC are involved in the expression of PPI in rodents. (C) 2011 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 09/07347-0 - Effect of apomorphine and haloperidol microinjection in the inferior colliculus on pre-pulse inhibition of acoustic startle reflex in rat
Grantee:Susan Yuri Satake
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 09/05703-4 - Effect of apomorphine and haloperidol microinjection in the inferior colliculus on prepulse inhibition of acoustic startle reflex in rat
Grantee:Regina Cláudia Barbosa da Silva
Support type: Regular Research Grants
FAPESP's process: 09/07278-9 - Effects of apomorphine and haloperidol microinjection in the inferior colliculus on prepulse inhibition of acoustic startle reflex in rat
Grantee:Karen Yukie Yamada
Support type: Scholarships in Brazil - Scientific Initiation