Polymorphisms in Inflammasome' Genes and Susceptibility to HIV-1 Infection

Author(s)

Pontillo, Alessandra ^[1] ; Oshiro, Telma M. ; Girardelli, Martina ^[2] ; Kamada, Anselmo J. ^[3] ; Crovella, Sergio ^[3] ; Duarte, Alberto J. S.

Affiliation

^[1] Univ Sao Paulo, Fac Med, Lab Med Invest Dermatol & Immunodeficiency, LIM 56, BR-05403000 Sao Paulo - Brazil

^[2] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste - Italy

^[3] Univ Fed Pernambuco, Dept Genet, Recife, PE - Brazil

• Document type: Journal article
• Source: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES; v. 59, n. 2, p. 121-125, FEB 1 2012.
• Web of Science Citations: 42

Abstract

The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection. (AU)

• FAPESP's process: 09/53575-5 - Possible role of inflammasome in the immune response against virus HIV-1
• Grantee: Alberto José da Silva Duarte
• Support Opportunities: Regular Research Grants