| Full text | |
| Author(s): |
Cassilhas, R. C.
[1]
;
Lee, K. S.
[2]
;
Fernandes, J.
[3]
;
Oliveira, M. G. M.
;
Tufik, S.
;
Meeusen, R.
[4]
;
de Mello, M. T.
[5, 1]
Total Authors: 7
|
| Affiliation: | [1] CEPE, Psychobiol & Exercise Res Ctr, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, UNIFESP, Dept Biochem, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Neurophysiol, UNIFESP, Sao Paulo - Brazil
[4] Vrije Univ Brussel, Dept Human Physiol & Sports Med, Brussels - Belgium
[5] UNIFESP Univ Fed Sao Paulo, Dept Psychobiol, CEPE Psychobiol & Exercise Res Ctr, BR-04020050 Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Neuroscience; v. 202, p. 309-317, JAN 27 2012. |
| Web of Science Citations: | 127 |
| Abstract | |
A growing body of scientific evidence indicates that exercise has a positive impact on human health, including neurological health. Aerobic exercise, which is supposed to enhance cardiovascular functions and metabolism, also induces neurotrophic factors that affect hippocampal neurons, thereby improving spatial learning and memory. Alternatively, little is known about the effect of resistance exercise on hippocampus-dependent memory, although this type of exercise is increasingly recommended to improve muscle strength and bone density and to prevent age-related disabilities. Therefore, we evaluated the effects of resistance training on spatial memory and the signaling pathways of brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1), comparing these effects with those of aerobic exercise. Adult male Wistar rats underwent 8 weeks of aerobic training on a treadmill (AERO group) or resistance training on a vertical ladder (RES group). Control and sham groups were also included. After the training period, both AERO and RES groups showed improved learning and spatial memory in a similar manner. However, both groups presented distinct signaling pathways. Although the AERO group showed increased level of IGF-1, BDNF, TrkB, and g-CaMKII (calcium/calmodulin-dependent kinase II) in the hippocampus, the RES group showed an induction of peripheral and hippocampal IGF-1 with concomitant activation of receptor for IGF-1 (IGF-1R) and AKT in the hippocampus. These distinct pathways culminated in an increase of synapsin 1 and synaptophysin expression in both groups. These findings demonstrated that both aerobic and resistance exercise can employ divergent molecular mechanisms but achieve similar results on learning and spatial memory. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 08/03083-6 - The influence of aerobic and resistance exercise on memory and the cerebral concentration of IGF-1 and BDNF in rats |
| Grantee: | Marco Túlio de Mello |
| Support Opportunities: | Regular Research Grants |